Objetivo: avaliar a eficácia da Ivermectina e do Atazanavir em comparação com placebo no tempo de resolução dos sintomas duração doença por COVID-19. Método: estudo observacional, coorte prospectivo, longitudinal, descritivo analítico pacientes sintomáticos ambulatoriais, acompanhados 06 meses duas Unidades Básicas Saúde para atendimento COVID-19 Teresina-Piauí, Brasil, período novembro abril 2...

Abstract Background Lumateperone is an FDA-approved antipsychotic to treat schizophrenia and depressive episodes associated with bipolar I or II disorder as monotherapy adjunctive therapy lithium valproate. This post hoc analysis investigated the efficacy tolerability of lumateperone in patients via number needed (NNT), harm (NNH), likelihood be helped harmed (LHH). Methods Data were pooled fro...

abstract background: fatigue is the most common side effect of chemotherapy in children with acute lymphoblastic leukemia (all).acupressure is one of the most popular non‑pharmacologic methods used to reduce fatigue in other settings. the aim of the study was to evaluate the effect of acupressure on reducing fatigue among children with all compared with a placebo treatment. materials and method...

Background Sickle cell nephropathy is a major cause of morbidity and mortality in sickle cell anaemia (SCA). Proteinuria contributes to progression of renal damage. Icroalbuminuria is an early feature of SCN and progression to advanced kidney damage is delayed if regression is achieved with angiotensin converting enzyme inhibitors. We aimed to ...

In this study, we investigated the impact of a controlled 4-day caffeine withdrawal period on the effect of an acute caffeine dose on endurance exercise performance. Twelve well-trained and familiarized male cyclists, who were caffeine consumers (from coffee and a range of other sources), were recruited for the study. A double-blind placebo-controlled cross-over design was employed, involving f...

Berotralstat is an oral plasma kallikrein inhibitor in development for HAE attack prophylaxis. characterized by unpredictable, episodic attacks; some patients experience frequent attacks without treatment. This analysis sought to understand whether baseline frequency correlates with responder rates berotralstat. 121 were randomized berotralstat 110 mg:150 mg:placebo daily 24 weeks a phase 3 dou...

Abstract Introduction Once-nightly sodium oxybate (ON-SXB; FT218), an investigational, extended-release treatment, was evaluated for the treatment of narcolepsy in adults phase 3 REST-ON clinical trial (NCT02720744). The co-primary endpoints, mean sleep latency on Maintenance Wakefulness Test (MWT), Clinical Global Impression-Improvement rating, and weekly number cataplexy attacks (NCA), second...

Background: Central nervous system (CNS) has limited repair capacity, and any spinal cord injury (SCI) can cause persistent disability in motor, sensory, autonomic functions. The harmful reactions around the lesion must be stopped to prevent this consequence. Objectives: present study compares clinical effects of methylprednisolone sodium succinate (MPSS) meloxicam acute an animal model rats. M...

BACKGROUND The beneficial effects of testosterone treatment (TT) are debated. METHODS Double-blinded, placebo-controlled study of six months TT (gel) in 54 men aged 60-78 with bioavailable testosterone (BioT) <7.3 nmol/L and waist >94 cm randomized to TT (50-100 mg/day, n = 20), placebo (n = 18), or strength training (ST) (n = 16) for 24 weeks. Moreover, the ST group was randomized to TT (n =...