نتایج جستجو برای: pla2

تعداد نتایج: 1363  

Journal: :JACC. Cardiovascular imaging 2015
Romain Capoulade Ablajan Mahmut Lionel Tastet Marie Arsenault Élisabeth Bédard Jean G Dumesnil Jean-Pierre Després Éric Larose Benoit J Arsenault Yohan Bossé Patrick Mathieu Philippe Pibarot

OBJECTIVES The purpose of this prospective study was to examine the relationship between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and the progression rate of aortic stenosis (AS). BACKGROUND We recently reported that Lp-PLA2 is highly expressed in stenotic aortic valves where it may contribute to the mineralization of valvular interstitial cells. METHODS Patients wi...

2015
Yan Wang Jin Zhang Yuesheng Qian Xiaofeng Tang Huawei Ling Kemin Chen Pingjin Gao Dingliang Zhu Xiaoying Wang

OBJECTIVE Intracranial arterial stenosis (ICAS) is a common cause of ischemic stroke in Asians, whereas whites tend to have more extracranial lesions. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been associated with ischemic stroke by a large amount of work. However, there are few studies focusing on the relationship of Lp-PLA2 and asymptomatic ICAS or extracranial arterial stenosis (...

Journal: :Journal of leukocyte biology 1996
J Takasaki Y Kawauchi T Yasunaga Y Masuho

To investigate the effect of type II phospholipase A2 (PLA2-II) on neutrophil function, we assessed the Mac-1 (CD11b/CD18) expression on human neutrophils by flow cytometry after incubation of the cells with human PLA2-II. PLA2-II at a concentration of 10 microg/mL increased the Mac-1 expression by 150% compared with unstimulated cells at 30 min and after. Under these conditions PLA2-II increas...

Journal: :The Biochemical journal 1992
M Spaargaren S Wissink L H Defize S W de Laat J Boonstra

The production of arachidonic acid (AA), which is involved in mitogenic signalling by epidermal growth factor (EGF), is most directly accomplished by the action of phospholipase A2 (PLA2). We demonstrate that EGF treatment of intact NEF cells rapidly activates a cytosolic PLA2, as measured in cell-free extracts by the release of radiolabelled AA from exogenously added 1-stearoyl-2-[1-14C]arachi...

Journal: :The Journal of endocrinology 1999
W Farrugia L Nicholls G E Rice

The aim of this study was to establish the effect of bacterial endotoxin lipopolysaccharide (LPS) on the release of Type II phospholipase-A2 (PLA2) and prostaglandin E2 (PGE2) from late-pregnant human placental tissue incubated in vitro. Under basal conditions, immunoreactive Type II PLA2 and PGE2 were released from tissue explants in a time-dependent manner (up to 24 h, ANOVA, P<0. 0001, n=6)....

2013
Sine Holst-Albrechtsen Maria Kjaergaard Anh-Nhi Thi Huynh Johanne Kragh Sorensen Susanne Hosbond Mads Nybo

Studies indicate that elevated plasma concentrations of lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with increased risk of cardiovascular disease. Lp-PLA2 seems to play a crucial role in the formation of plaques and acute inflammation, and plasma Lp-PLA2 could therefore potentially be used as a predictor of long-term outcome in ACS patients. To evaluate this, data concerning...

Journal: :Analytical biochemistry 1997
Y Kim L Lichtenbergova Y Snitko W Cho

A novel kinetic and membrane-binding assay for phospholipase A2 (PLA2) has been developed utilizing phospholipid-coated hydrophobic styrene-divinylbenzene beads (5.2 +/- 0.3 microm diameter). Phospholipids formed a stable monolayer film on styrene-divinylbenzene beads with average surface packing density of (1.3 +/- 0.2) x 10(-2) molecule/A2. Secretory PLA2 readily hydrolyzed 1-palmitoyl-2-[3H]...

Journal: :nephro-urology monthly 0
mohammadreza ardalan nephrology department, tabriz university of medical sciences, ir iran; }iroopnwo~oostmtuvumont husoskloiwe~s{u{eovcmedical sciences, tabriz, ir iran. 2) mario negriinstitute of pharmacological research, italy +98-4113344339, [email protected]; }iroopnwo~oostmtuvumont husoskloiwe~s{u{eovcmedical sciences, tabriz, ir iran. 2) mario negriinstitute of pharmacological research, italy +98-4113344339, [email protected]

introduction idiopathic membranous nephropathy (mn) is a common cause of adult nephrotic syndrome. recently, m-type phospholipase a2 receptor (pla2-r) has been discovered as the main podocyte antigen in the pathogenesis of idiopathic mn. materials and methods in this mini review, the author searched english-language medline for the terms “membranous nephropathy”, “rituximab”, and “phospholipase...

Journal: :Biophysical Chemistry 2021

Abstract Elucidating electrokinetic stability by which surface charges regulate toxins interaction with erythrocytes is crucial for understanding the cell functionality. Electrokinetic properties of human upon treatment Vipoxin, phospholipase A2 (PLA2) and Vipoxin acidic component (VAC), isolated from Vipera ammodytes meridionalis venom were studied using particle microelectrophoresis. PLA2 tre...

2013
Hui Cai Elena G. Chiorean Michael V. Chiorean Douglas K. Rex Bruce W. Robb Noah M. Hahn Ziyue Liu Patrick J. Loehrer Marietta L. Harrison Yan Xu

Only in recent years have phospholipase A2 enzymes (PLA2s) emerged as cancer targets. In this work, we report the first detection of elevated PLA2 activities in plasma from patients with colorectal, lung, pancreatic, and bladder cancers as compared to healthy controls. Independent sets of clinical plasma samples were obtained from two different sites. The first set was from patients with colore...

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