This study aimed to investigate the sustained drug release properties and hearing protection effect of polyethylene glycol-coated polylactic acid (PEG-PLA) stealth nanoparticles loaded with dexamethasone (DEX). DEX was fabricated into PEG-PLA nanoparticles using an emulsion and evaporation technique, as previously reported. The DEX-loaded PEG-PLA nanoparticles (DEX-NPs) had a hydrodynamic diame...

BACKGROUND AND AIMS Advances in the treatment of cervical cancer over the last decade have predominantly involved the development of genes directed at molecular targets. Gene therapy is recognized to be a novel method for the treatment of cervical cancer. Genes can be administered into target cells via nanocarriers. This study aimed to develop systemically administrable nano-vectors. Floate (Fa...

• When PLA/PEG/Chitosan/FA/DNA nanoparticles interact with MCF-7 cells, their loading percentage and biocompatibility improve. Physicochemical properties of for properly targeted transfer to cells. An increase in Chitosan-FA on gene efficiency was seen positively by nanoparticles. The ability Chitosan-Folic acid PLA-PEG polymers delivery into cells evaluated. copolymer is one the most appealing...

BACKGROUND Adhesions frequently occur after abdominal surgery. Many anti-adhesion products have been used in clinic. However, the evidences are short for surgeons to reasonably choose the suitable anti-adhesion produces in clinical practice. This study provided such evidence by comparing the efficiency of five products to prevent abdominal adhesion formation in a rat model. METHODS Fifty-six ...

There are increasing numbers of developed nanocarriers for anticancer drug delivery in the aim to avoid side effects conventional chemotherapy. Filomicelles with folic acid (FA) as a targeting moiety novel approach that can potentially maximize therapeutic efficacy while minimizing effects. The this study was analyze influence composition PLA-based micelles functionalized on their encapsulation...

Background: PLA-PEG-PLA triblock polymer nanoparticles are promising tools for targeted dug delivery. The main aim in designing polymeric nanoparticles for drug delivery is achieving a controlled and targeted release of a specific drug at the therapeutically optimal rate and choosing a suitable preparation method to encapsulate the drug efficiently, which depends mainly on the nature of the dru...