نتایج جستجو برای: pkm2

تعداد نتایج: 844  

2016
Chang-Liang He Yang-Yang Bian Yu Xue Ze-Xian Liu Kai-Qiang Zhou Cui-Fang Yao Yan Lin Han-Fa Zou Fang-Xiu Luo Yuan-Yuan Qu Jian-Yuan Zhao Ming-Liang Ye Shi-Min Zhao Wei Xu

In cancer cells, the mammalian target of rapamycin complex 1 (mTORC1) that requires hormonal and nutrient signals for its activation, is constitutively activated. We found that overexpression of pyruvate kinase M2 (PKM2) activates mTORC1 signaling through phosphorylating mTORC1 inhibitor AKT1 substrate 1 (AKT1S1). An unbiased quantitative phosphoproteomic survey identified 974 PKM2 substrates, ...

2016
Raju V. S. Rajala Ammaji Rajala Christopher Kooker Yuhong Wang Robert E. Anderson

The tumor form of pyruvate kinase M2 (PKM2) undergoes tyrosine phosphorylation and gives rise to the Warburg effect. The Warburg effect defines a pro-oncogenic metabolism switch such that cancer cells take up more glucose than normal tissue and favor incomplete oxidation of glucose, even in the presence of oxygen. Retinal photoreceptors are highly metabolic and their energy consumption is equiv...

2016
Rui Zhao Lei Li Jinbo Yang

Hepatocellular carcinoma (HCC) is the fifth common malignant tumor worldwide and has the characteristics of insidious onset, high malignancy, invasive fast-growth, high recurrence and poor prognosis. Currently, besides the alpha-fetoprotein (AFP), there are still no other markers for the accurate HCC diagnosis. Emerging evidence shows that pyruvate kinase isozyme splice variant 2 (PKM2) is high...

2012
Mohd Askandar Iqbal Rameshwar N. K. Bamezai

Metabolism of cancer cells with pyruvate kinase M2 (PKM2) at its centre stage has assumed a prime significance in cancer research in recent times. Cancer cell metabolism, characterized by enhanced glucose uptake, production of lactate and anabolism is considered an ideal target for therapeutic interventions. Expression of PKM2 switches metabolism in favor of cancer cells, therefore, the present...

Journal: :Neuro-oncology 2010
Benjamin Kefas Laurey Comeau Nicholas Erdle Emmitt Montgomery Samson Amos Benjamin Purow

Emerging studies have identified microRNAs (miRNAs) as possible therapeutic tools for the treatment of glioma, the most aggressive brain tumor. Their important targets in this tumor are not well understood. We recently found that the Notch pathway is a target of miRNA-326. Ectopic expression of miRNA-326 in glioma and glioma stem cells induced their apoptosis and reduced their metabolic activit...

2012
Dimitrios Anastasiou Yimin Yu William J. Israelsen Jian-kang Jiang Matthew B. Boxer Bum Soo Hong Wolfram Tempel Svetoslav Dimov Min Shen Abhishek Jha Hua Yang Katherine R. Mattaini Christian M. Metallo Brian P. Fiske Kevin D. Courtney Scott Malstrom Tahsin M. Khan Charles Kung Amanda P. Skoumbourdis Henrike Veith Noel Southall Martin J. Walsh Kyle R. Brimacombe William Leister Sophia Y. Lunt Zachary R. Johnson Katharine E. Yen Kaiko Kunii Shawn M. Davidson Heather R. Christofk Christopher P. Austin James Inglese Marian H. Harris John M. Asara Gregory Stephanopoulos Francesco G. Salituro Shengfang Jin Lenny Dang Douglas S. Auld Hee-Won Park Lewis C. Cantley Craig J. Thomas Matthew G. Vander Heiden

Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer. The interaction of PKM2 with phosphotyrosine-containing proteins inhibits enzyme activity and increases the availability of glycolytic metabolites to support cell proliferation. This suggests tha...

2014
Yuhui Jiang Yugang Wang Ting Wang David H. Hawke Yanhua Zheng Xinjian Li Qin Zhou Sadhan Majumder Erfei Bi David X. Liu Suyun Huang Zhimin Lu

Pyruvate kinase M2 (PKM2) is expressed at high levels during embryonic development and tumour progression and is important for cell growth. However, it is not known whether it directly controls cell division. Here, we found that Aurora B phosphorylates PKM2, but not PKM1, at T45; this phosphorylation is required for PKM2's localization and interaction with myosin light chain 2 (MLC2) in the con...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Atsushi Hamabe Masamitsu Konno Nobuhiro Tanuma Hiroshi Shima Kenta Tsunekuni Koichi Kawamoto Naohiro Nishida Jun Koseki Koshi Mimori Noriko Gotoh Hirofumi Yamamoto Yuichiro Doki Masaki Mori Hideshi Ishii

Pyruvate kinase M2 (PKM2) is an alternatively spliced variant of the pyruvate kinase gene that is preferentially expressed during embryonic development and in cancer cells. PKM2 alters the final rate-limiting step of glycolysis, resulting in the cancer-specific Warburg effect (also referred to as aerobic glycolysis). Although previous reports suggest that PKM2 functions in nonmetabolic transcri...

2012
Zhimin Lu

In the presence of oxygen, most differentiated cells generate the energy needed for cellular processes primarily by metabolizing glucose to carbon dioxide by oxidation of glycolytic pyruvate in the mitochondrial tricarboxylic acid cycle. When oxygen becomes limited, differentiated cells produce large amounts of lactate. In contrast, most cancer cells have increased glucose uptake and metabolize...

2017
Eva M. Palsson-McDermott Lydia Dyck Zbigniew Zasłona Deepthi Menon Anne F. McGettrick Kingston H. G. Mills Luke A. O’Neill

Blocking interaction of the immune checkpoint receptor PD-1 with its ligand PD-L1 is associated with good clinical outcomes in a broad variety of malignancies. High levels of PD-L1 promote tumor growth by restraining CD8+ T-cell responses against tumors. Limiting PD-L1 expression and function is therefore critical for allowing the development of antitumor immune responses and effective tumor cl...

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