Hepatocellular carcinoma (HCC) is the fifth common malignant tumor worldwide and has the characteristics of insidious onset, high malignancy, invasive fast-growth, high recurrence and poor prognosis. Currently, besides the alpha-fetoprotein (AFP), there are still no other markers for the accurate HCC diagnosis. Emerging evidence shows that pyruvate kinase isozyme splice variant 2 (PKM2) is high...