The protein expressions of steroidogenic factor l (SF-l) and pituitary-specific transcription factor 1 (Pit-1) were investigated immunohistochemically for 53 spontaneous pituitary adenomas of the pars distalis from male Crl:CD(SD) rats. Luteinizing hormone (LH)-positive/prolactin (PRL)-negative and LH-negative/PRL-positive adenomas showed that the expression of SF-1 and Pit-1 was exclusively re...

An early step in generating specific cell types in embryos involves the commitment of multipotent stem cells to specific lineages. The anterior pituitary gland, with its five cell types originating from a common precursor, provides an instructive model to approach the mechanisms that control mammalian organ development and cell differentiation. Using the well-known model of the Ames dwarf mouse...

BACKGROUND/AIMS Members of the SLC20 cotransporter family (PiT-1, PiT-2) are ubiquitously expressed in mammalian tissue and are thought to perform housekeeping functions for intracellular Pi homeostasis as well as being implicated in vascular calcification and renal Pi reabsorption. The aims of this study were to investigate the topology of a linker region in PiT-1 between the predicted 2(nd) a...

Introduction: Central pit craters are an unusual class of impact crater seen most commonly on the icy Galilean satellites and Mars. They are characterized by terraced rims and flattened floors with a pit at or near the center (see Fig 1). Their association with ice-rich surfaces has led most hypotheses for the origins of central pits to rely on the volatility or weakness of water ice [e.g. 1, 2...

Abstract Pit-1 (POU1F1) is a POU-homeodomain transcription factor, and it one of the most important tissue-specific factors in pituitary development. Cyclin-dependent kinase 5 (CDK5) protein that can phosphorylate many key factors, but mechanism under which CDK5 phosphorylates unclear. To investigate whether regulate cell proliferation promote hormone secretion through phosphorylation Ser126-Pi...

the determination of the ultimate pit limit (upl) is the first step in the open pit mine planning process. in this stage that parts of the mineral deposit that are economic to mine are determined. there are several mathematical, heuristic and meta-heuristic algorithms to determine upl. the optimization criterion in these algorithms is maximization of the total profit whilst satisfying the...

The complete amino acid sequence of the p453-plasmid-mediated PIT-2 ,-lactamase (SHV1) was determined. The protein contains 265 residues. Peptides resulting from digestions with trypsin, Staphylococcus aureus V8 proteinase, chymotrypsin and Lys-C proteinase and cleavage with CNBr were separated and purified by using reverse-phase h.p.l.c. The amino acid sequence of each peptide was manually det...