Patients with HIV have higher risk of developing squamous cell carcinoma of the skin given the increased risk of HPV infection, which alters cell proliferation and apoptosis [1]. Pigmented Bowen's disease is an uncommon form of squamous cell carcinoma in-situ characterized by pigmented lesions that can clinically mimic superficial spreading melanoma, pigmented basal cell carcinoma, melanocytic ...

Canine papillomaviruses (CPVs) have been identified in various benign and malignant neoplastic skin disorders. The most frequent manifestations of CPV infections are classical warts and pigmented plaques. Although the etiology of canine oral papillomatosis is well established, knowledge about CPVs role in the development of pigmented plaques remains vague. Indeed, as CPV DNA may frequently be f...

Retinal pigmented epithelial cells exchange their cellular phenotypes into lens cells and neurons, via depigmented and non-epithelial-shaped dedifferentiated intermediates. Because these dedifferentiated cells can either revert to pigmented epithelial cells or transdifferentiate into lens cells and/or neurons, they are recognized as candidates for lens and retinal cell regeneration. The purpose...

A lthough the benefits of using dermoscopy as a diagnostic aid are well described, dermoscopy currently remains underutilized in the United States. According to a recent survey of US academic dermatologists, reasons cited for lack of utilization included lack of training, logistical constraints, and the belief that the procedure was not helpful. Also, some clinicians may be apprehensive about i...

Sekiguchi-Tonosaki M, Obata M, Haruki A, Himi T, Kosaka J. Acetylcholine induces Ca signaling in chicken retinal pigmented epithelial cells during dedifferentiation. Am J Physiol Cell Physiol 296: C1195–C1206, 2009. First published February 25, 2009; doi:10.1152/ajpcell.00423.2008.—Retinal pigmented epithelial cells exchange their cellular phenotypes into lens cells and neurons, via depigmented...