After 15 years of development of instruction sequence theory (IST) writing a SWOT analysis about that project is long overdue. The paper provides a comprehensive SWOT analysis of IST based on a recent proposal concerning the terminology for the theory and applications of instruction sequences.

Pitch recognition was required alter a 4-sec. delay during which 4 other tones were played. When the standard (S) and comparison (C) tones were identical in pitch, the inclusion of a tone in the intervening sequence that was a semitone higher or lower than the S tone produced an increase in errors. Including tones both a semitone higher and a semitone lower in the same intervening sequence prod...

Recognizing structural similarity without significant sequence identity has proved to be a challenging task. Sequence-based and structure-based methods as well as their combinations have been developed. Here, we propose a fold-recognition method that incorporates structural information without the need of sequence-to-structure threading. This is accomplished by generating sequence profiles from...

It has recently been claimed that the outstanding performance of machine-learning scoring functions (SFs) is exclusively due to the presence of training complexes with highly similar proteins to those in the test set. Here, we revisit this question using 24 similarity-based training sets, a widely used test set, and four SFs. Three of these SFs employ machine learning instead of the classical l...

We define a p-adic character to be a continuous homomorphism from 1 + tFq [[t]] to Zp. For p > 2, we use the ring of big Witt vectors over Fq to exhibit a bijection between p-adic characters and sequences (ci)(i,p)=1 of elements in Zq , indexed by natural numbers relatively prime to p, and for which limi→∞ ci = 0. To such a p-adic character we associate an L-function, and we prove that this L-f...

Introduction: Nager syndrome is a malformation resulting from problems in the development of the first and second branchial arches and limb buds. The cause of the abnormal development of the pharyngeal arches in Nager syndrome is unknown. It is also unclear why affected individuals have bone abnormalities in their arms and legs. Nager syndrome is thought to have an autosomal recessive inherita...