The recent widespread prohibition of kava-kava (“kava”, Piper methysticum) has raised fundamental questions about the regulation of herbal medicines. A remedy with established efficacy and long standing popularity has been withdrawn, with severe damage to the economies of several small Pacific nations, on the basis of uncertain reports linking its consumption to liver damage. No rigorous assess...

Bioassay-guided fractionation of Chimaphila umbellata (L.) W. Bart (Pyrolaceae) ethanol extracts led to the identification of 2,7-dimethyl-1,4-naphthoquinone (chimaphilin) as the principal antifungal component. The structure of chimaphilin was confirmed by 1H and 13C NMR spectroscopy. The antifungal activity of chimaphilin was evaluated using the microdilution method with Saccharomyces cerevisi...

ETHNOPHARMACOLOGICAL RELEVANCE This paper presents one of the first large-scale collaborative research projects in ethnopharmacology, to bring together indigenous stakeholders and scientists both in project design and execution. This approach has often been recommended but rarely put into practice. The study was carried out in two key indigenous areas of Guatemala, for which very little ethnoph...

context ginger is the rhizome of zingiber officinale, a perennial plant, used alone or in compounds as a spice or remedy in ancient recipes of iranian traditional medicine (itm) as an effective tonic for the memory and digestive system, the opener of hepatic obstructions, aphrodisiac, for expelling compact wind from stomach and intestines, diluting, desiccating and emollient of phlegmatic and c...

Helicobacter pylori (H. pylori) successfully colonizes the human stomach of the majority of the human population. This infection always causes chronic gastritis, but may evolve to serious outcomes, such as peptic ulcer, gastric carcinoma or mucosa-associated lymphoid tissue lymphoma. H. pylori first line therapy recommended by the Maastricht-4 Consensus Report comprises the use of two antibioti...

The plant Pergularia daemia has been traditionally used as anthelmintic, laxative, antipyretic expectorant and also used to treat infantile diarrhea and malarial intermittent fevers. It is widely distributed in the tropical and sub tropical regions of the world. Various phytochemical including terpenoid, flavonoids, sterols and cardenolids have been isolated and identified from the various part...

Nanotechnology has rapidly grown in various research fields to treat oxidative stress diabetes, including medicine and phytomedicine. Previous showed that Acalypha hispida strong antioxidant activity vitro anti-hyperglycemic vivo. However, the size reduction crude extract should be applied decrease doses increase efficacy. The objective was evaluate nano-extract of A. leaves on Cu,Zn-SOD conten...

BACKGROUND In our previous studies, it was evident that the dichloromethane-methanol (1:1 v/v) stem barks extract of Polyscias fulva and fractions (ethyl acetate, n-butanol and residue) demonstrated interesting antidermatophytic activities. So, as a continuity of that, this work aimed at identifying active principles with antifungal properties from P. fulva that could be used as markers for pos...