We have previously reported 1 that cells of the Graffi leukaemia, an experimental tumor of the mouse, irradiated with long wave UV light in the presence of skin-photosensitizing furocoumarins (psoralens), lose their tumor-transmitting capacity when transplanted into adult mice. This result can be explained by the C4-photocycloaddition that these drugs yield to the pyrimidine bases of DNA and R ...

pharmaceuticals for possible carcinogenic effects: initial positive results for drugs not previously screened.matologic effects of cardiovascular drug therapy: part II. Cardiol Rev. 2002; 10(5):285-300. 6. Krieger N. Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. Incidence of cancers in people with HIV/AIDS compared wit...

We investigated the photosensitizing properties of secondary organic aerosol (SOA) formed during hydroxyl radical (OH) initiated oxidation naphthalene. This SOA was injected into an flow tube and exposed to UV radiation gaseous volatile compounds or sulfur dioxide (SO2). The particles were observed grow in size by photosensitized uptake d-limonene β-pinene. In presence SO2, a production (0.2–0....

Melasma is a hyperpigmented dermatological condition common in females. Drugs such as steroids, cosmetics, and photosensitizing agents are known to cause melasma. We report here a case of an adult male with obsessive-compulsive disorder, receiving clomipramine, who developed melasma.

Photodynamic therapy is a technique that consists of activating Photosensitizing Agent (PS) to form reactive oxygen species, which are important for antimicrobial action. This research aimed carry out laboratory tests measure singlet oxygenand superoxide radicals release as function different formulations and concentrations methylene blue (MB), eosin Y (EY) fluorescein (FL) dyes, compare their ...

It was demonstrated that anthraquinone-rich extracts, obtained from the phototoxic vegetal species Heterophyllaea pustulata Hook f. (Rubiaceae), exhibited bacteriostatic activity on Micrococcus luteus ATCC 9341, selectively inhibiting both oxacillin-sensitive and resistant Staphylococcus aureus, and antifungal activity against important opportunist microorganisms and against those involved in s...

Toxic reactants are a common result of the interaction of sunlight with pharmaceutical agents transported in the blood system or applied topically. Over the past decade there has been a considerable amount of research toward understanding both the unimolecular deactivation pathway of photoexcited pharmaceutical products and their photosensitizing capability in the presence of biological substra...