Photodynamic therapy (PDT) is a tumor-ablative and function-sparing oncologic intervention. The relative simplicity of photosensitizer application followed by light activation resulting in the cytotoxic and vasculartoxic photodynamic reaction has allowed PDT to reach a worldwide audience. With several commercially available photosensitizing agents now on the market, numerous well designed clini...

In photodynamic therapy (PDT), a tumor-selective photosensitizer is administered and then activated by exposure to a light source of applicable wavelength. Multidrug resistance (MDR) is largely caused by the efflux of therapeutics from the tumor cell by means of P-glycoprotein (P-gp), resulting in reduced efficacy of the anticancer therapy. This study deals with photodynamic therapy with Photof...

BACKGROUND After repeated injections of VEGF inhibitors for wet AMD some patients show therapy-resistant isolated subretinal fluid (here named secondary sick RPE syndrome). The efficacy of photodynamic therapy was examined in these cases. PATIENTS AND METHODS A group of in total 18 patients with wet AMD (14 eyes with occult and 4 with minimal classic CNV) showed therapy-resistant isolated sub...

We have synthesized a novel, two-photon-absorbing photosensitizer for two-photon-absorption photodynamic therapy (2PA-PDT). The molecule is a butadiyne-bridged porphyrin dimer terminated with two water-soluble porphyrin monomers connected through Zn-imidazolyl self-assembly and covalently linked through olefin metathesis. It has an effective two-photon-absorption (2PA) cross-section value, sigm...

Introduction Studies in our laboratory focus on development of vascular targeted photodynamic therapy (VTP) based on bacteriochlorophyll derivatives as photosensitizer drugs, elucidation of its mechanism of action and development of new applications for photodynamic therapy (PDT) such as treatment of Extrauterine Pregnancy (EUP). These studies are in collaboration with Prof. Avigdor Scherz Dept...

Aflibercept (Eylea) injection (CPB 0701 Vascular Endothelial Growth Factor Inhibitors for Ocular Indications) Bevacizumab (Avastin) injection (CPB 0685 Bevacizumab (Avastin)) Pegaptanib sodium (Macugen) injection (CPB 0701 Vascular Endothelial Growth Factor Inhibitors for Ocular Indications) Photodynamic therapy (PDT) with light-activated verteporfin (CPB 0594 Visudyne (Verteporfin) Photodynami...

OBJECTIVE This study evaluated the effects of photodynamic therapy (PDT) on buccal candidiasis in mice and on the adherence of yeast to buccal epithelial cells (BECs) in vitro. STUDY DESIGN A total of 56 immunosuppressed mice with buccal candidiasis were subjected to PDT, consisting of treatment with erythrosine (400 μmol/L) followed by exposure to a green LED (14.34 J cm(-2)). After treatmen...

The review presents the data on the use of photodynamic therapy (PDT) for the treatment of patients with malignant brain tumors. One and two-year survival rate and an increase in overall median survival of PDT-treated patients compared with standard treatment indicate a promising prospects for PDT in neurooncology.

Photodynamic therapy (PDT) procedure has minimum invasiveness in contrast to conventional anticancer surgical procedures. Although clinically approved a few decades ago, it is not commonly used due its poor efficacy, mainly light penetration into deeper tissues. PDT uses photosensitizer (PS), which photoactivated on illumination by of appropriate wavelength and oxygen the tissue, leading series...

A murine model of cutaneous leishmaniasis with green fluorescent protein positive (GFP+) L. major enables the monitoring of parasitic load via measurements of GFP fluorescence intensity, allowing for a faster and more efficient way of monitoring the clinical outcome of photodynamic therapy (PDT). This model may provide new insights on the phototoxic aspects in PDT. Although PDT regimens may be ...