objective(s)   although photodynamic therapy is considered as a noninvasive method, most photosensitizers are susceptible to  ultrasound.  therefore,  it  is  expected  that  the  combination of  two  activation  methods  might  have  a synergistic effect. this probable effect has been investigated in this study.   materials and methods   this  study  was  conducted  on  colon  carcinoma  tumor...

PURPOSE To report a case of familial exudative vitreoretinopathy with a retinal capillary angioma and persistent macular exudation treated with photodynamic therapy. DESIGN Interventional case report. METHODS A 39-year-old woman with familial exudative vitreoretinopathy presented with an intraretinal capillary angioma temporally with persistent macular exudation despite previous vitrectomy ...

Skin mycoses are caused mainly by dermatophytes, which are fungal species that primarily infect areas rich in keratin such as hair, nails, and skin. Significantly, there are increasing rates of antimicrobial resistance among dermatophytes, especially for Trichophyton rubrum, the most frequent etiologic agent worldwide. Hence, investigators have been developing new therapeutic approaches, includ...

General application of continuous-wave (CW) laser irradiation modes in photodynamic therapy can cause thermal damage to normal tissues in addition to tumors. A new photodynamic laser therapy system using a pulse irradiation mode was optimized to reduce nonspecific thermal damage. In in vitro tissue specimens, tissue energy deposition rates were measured in three irradiation modes, CW, pulse, an...

Antimicrobial photodynamic inactivation is currently being widely considered as alternative to antibiotic chemotherapy of infective diseases, attracting much attention to design of novel effective photosensitizers. Carboranyl-chlorin-e6 (the conjugate of chlorin e6 with carborane), applied here for the first time for antimicrobial photodynamic inactivation, appeared to be much stronger than chl...

Photodynamic Therapy (PDT) has been developing rapidly within various medical specialties since the 1980s. It matured as a feasible medical technology in the 1980s thought the world. Photodynamic Therapy (PDT) includes two steps of process. The first step is administration of a photosensitizer (PS) and the second step is activation by light lamination at an appropriate wave length to reactive t...

Abstract Owing to strong and tunable surface plasmon resonance (SPR) effect good biocompatibility, gold nanoparticles have been suggested be a versatile platform for broad range of biomedical applications. In this study, new nanoplatform thermo-responsive polymer encapsulated nanorods incorporating indocyanine green (ICG) was designed couple the photothermal properties (AuNRs) photodynamic ICG ...

The aim of the present work was to recognize the reasons for differences in the photodynamic action of dyes against various bacterial strains. It is expected that a better understanding of this problem may help in design of new photosensitizers. The sensitivity of 6 various bacterial strains to the photodynamic action of 5 photosensitizers was determined. The hydrophobicity of cell surface and ...

Photodynamic disinfection is a new method for cleaning dentures of edentulous patients. It is based on the photochemical action of a photoactive dye (photosensitizer), activated by proper light in the presence of oxygen. The mechanism of photosensitization directs the generation of reactive oxygen species that destroy the pathogens. A pilot study of photodynamic disinfection of dentures was car...

In the surgical multimodal management of malignant pleural mesothelioma, it seems crucial to proceed with an efficient local adjuvant treatment to kill residual tumor cells. Intrapleural photodynamic therapy has recently emerged as a potential candidate in this goal. In this review, we analyzed and classified 16 articles in which patients with malignant pleural mesothelioma received intrapleura...