PURPOSE To examine whether laser photocoagulation increased production of growth factors and cytokines, especially transforming growth factor-beta 2 (TGF-beta 2), by cultured human retinal pigment epithelial (RPE) cells. METHODS Dot blot analysis was performed to identify the changes using the conditioned medium of cultured human RPE cells with or without laser photocoagulation. The following...

PURPOSE This study was conducted to determine changes in the expression of vascular endothelial growth factor (VEGF) in murine retina after retinal scatter laser photocoagulation. METHODS Photocoagulation (PHC) was performed on wild-type C57BL/6J mice using a diode laser, and the eyes were enucleated 1, 2, 3, 4, 7, and 14 days after laser treatment. VEGF and monocyte chemoattractant protein (...

PURPOSE To evaluate visual results and vitreoretinopathy and retinal detachment frequencies in patients with and without prophylactic pre-equatorial retinal photocoagulation, who underwent clear lens extraction (CLE) to correct myopia. METHODS Thirty-five patients (60 eyes) that underwent clear lens extraction at the "Fundação Altino Ventura" had median follow-up of 20.5 months. They were cla...

PURPOSE Conventional retinal photocoagulation produces irregular lesions and does not allow reliable control of ophthalmoscopically invisible lesions. We applied automatically controlled retinal photocoagulation, which allows to apply uniform lesions without titration, and aimed at five different predictable lesion intensities in a study on rabbit eyes. METHODS A conventional 532-nm photocoag...

PURPOSE Choroidal neovascularization (CNV) under the age of 50 is more often observed in women than in men. The effects of 17beta-estradiol (E2) on choroidal neovascularization development were investigated both in animal models and cultured cells to see if estrogen receptors (ERs) are involved in the process. METHODS CNV was induced by fundus laser photocoagulation in adult male and female r...

f l t i s e r m s c i t d o o ( t m s a e Diabetic retinopathy (DR) remains the leading cause of blindness among working-age people in developed countries1. Tight control of blood glucose levels and blood pressure is essential for preventing or arresting DR development. However, therapeutic objectives are difficult to achieve and DR therefore occurs in a high proportion of patients. Once DR app...

Purpose To investigate the effect of the vascular adhesion protein-1 (VAP-1) inhibitor RTU-1096 on retinal morphologic changes and ocular inflammation after retinal laser photocoagulation in mice. Methods C57BL/6JJcl mice were fed a diet containing RTU-1096, a specific inhibitor for VAP-1, or a control diet ad libitum for 7 days. Laser photocoagulation was performed on the peripheral retina o...

OBJECTIVE To report the management of retinal angiomatous proliferation (RAP), a recently described intraretinal neovascular lesion occurring in age-related macular degeneration. METHODS This was a retrospective review of consecutive patients with age-related macular degeneration who underwent treatment of RAP from January 1, 2000, through January 31, 2003. Inclusion criteria were age 55 year...