نتایج جستجو برای: phenylthiocarbamide ptc
تعداد نتایج: 3669 فیلتر نتایج به سال:
Many exogenous and endogenous factors are involved in the development of peptic ulcers. These factors are of individual importance for each subject and probably vary with time (Vesely, Kubickova', and Dvoraikova, 1968). At present, great importance is ascribed to hereditary factors, though it is difficult to produce the necessary evidence (Bauer and Aschner, 1922; Fuirst, 1936; Dubarry, Pisot, ...
Mammalian type 2 taste receptors (T2R) are a family of G protein-coupled receptors that mediate bitter signals in taste cells. In the present study, we compared the genomic organization of rodent T2R genes based on the recently completed mouse and rat genomes and examined tissue- and cell-specific expression of T2Rs. Both mouse and rat T2R families consist of 36 intact genes and at least 7 pseu...
Richter and Clisby (1) have investigated the t,oxic effect of phenylthiocarbamide in rats. The acute toxic effect is characterized by an effusion of fluid into the thoracic cavity, but in chronic poisoning there is a lowered body temperature, which suggests a depression of metabolism, and compensatory changes in the thyroid. It was therefore of interest to test the effect of the drug in vitro o...
The human TAS2R38 receptor is believed to be partly responsible for the ability to taste phenylthiocarbamide (PTC), a bitter compound very similar to the bitter glucosinolates found in brassica vegetables. These vegetables and their active compounds have chemo-protective properties. This study investigated the relationship between genetic variation in the hTAS2R38 receptor and the actual consum...
The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. However, recent high-resolution population genetic studies of TAS2Rs suggest that demographic events ...
Bitter molecules in humans are detected by ∼25 G protein-coupled receptors (GPCRs). The lack of atomic resolution structure for any of them is complicating an in depth understanding of the molecular mechanisms underlying bitter taste perception. Here, we investigate the molecular determinants of the interaction of the TAS2R38 bitter taste receptor with its agonists phenylthiocarbamide (PTC) and...
Variation in human taste is a well-known phenomenon. However, little is known about the molecular basis for it. Bitter taste in humans is believed to be mediated by a family of 25 G protein-coupled receptors (hT2Rs, or TAS2Rs). Despite recent progress in the functional expression of hT2Rs in vitro, up until now, hT2R38, a receptor for phenylthiocarbamide (PTC), was the only gene directly linked...
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