نتایج جستجو برای: phenylpyrrolidine 25 dione

تعداد نتایج: 359816  

Journal: :Journal of medicinal chemistry 2010
Xiaofeng Liu Hua Xie Cheng Luo Linjiang Tong Yi Wang Ting Peng Jian Ding Hualiang Jiang Honglin Li

Insulin-like growth factor-1 receptor (IGF-1R) is a growth factor receptor tyrosine kinase acting as a critical mediator of cell proliferation and survival. Novel 5-benzylidenethiazolidine-2,4-dione (5) and 5-(furan-2-ylmethylene)thiazolidine-2,4-dione (6) compounds were identified as potent and selective IGF-1R inhibitors via hierarchical virtual screening. Initial SAR and biological activity ...

ژورنال: :محیط زیست جانوری 0
زهرا درخشانپور گروه زیست شناسی، دانشگاه آزاد اسلامی واحد دامغان ویدا حجتی گروه زیست شناسی، دانشگاه آزاد اسلامی واحد دامغان حسین عباسپور گروه زیست شناسی، دانشگاه آزاد اسلامی واحد دامغان

منطقه حفاظت شده پرور در استان سمنان در شمال شرقی شهرستان سمنان قراردارد. این منطقه به دلیل تنوع اقلیمی فراوان دارای فون و فلوری غنی می باشد. این مطالعه به منظور بررسی فون مارهای منطقه حفاظت شده پرور از فروردین تا اواخر شهریور ماه 1392 انجام شد. نمونه برداری از ساعات اولیه صبح تا اواخر شب در نقاط مختلف منطقه انجام گرفت. نمونه ها پس از جمع آوری به آزمایشگاه منتقل شدند و پس از شناسایی از نظر صفات ...

2005
EUAN H. D. CAMERON

The localization and some characteristics of mouse adrenal C19-steroid 5fi-reductase were determined by the incubation of subcellular fractions of mouse adrenal tissue with [7a-3H]androst-4-ene-3,17-dione. This enzyme was present only in the soluble fraction and was NADPH-dependent, although a small activity in the presence ofNADH was also detected. The soluble fraction also contained 3 a-, 3,6...

2012
Ke Zhang Francis Nimmo

An inferred ancient episode of heating and deformation on Tethys has been attributed to its passage through a 3:2 resonance with Dione (Chen, E.M.A., Nimmo, F. [2008]. Geophys. Res. Lett. 35, 19203). The satellites encounter, and are trapped into, the e-Dione resonance before reaching the e-Tethys resonance, limiting the degree to which Tethys is tidally heated. However, for an initial Dione ec...

2017
Weiyi Wang Fanglan Ge Caihong Ma Jiang Li Yao Ren Wei Li Jinsong Fu

3-Ketosteroid-∆1-dehydrogenase (KstD), a key enzyme in microbial steroid catabolism, catalyzes the trans-axial elimination of the C1 and C2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids, and it was usually used to transform androst-4-ene-3,17-dione (AD) to produce androsta-1,4-diene-3,17-dione. Here, the KstD from Gordonia neofelifaecis was expressed efficien...

Journal: :Biomedical chromatography : BMC 2008
Rada Baosić Ana Radojević Milanka Radulović Srdan Miletić Maja Natić Zivoslav Tesić

The lipophilicity of a series of Schiff base ligands and their complexes with nickel(II) and copper(II) has been determined by reversed-phase thin-layer chromatography using binary dioxane-water mobile phase. Chelate ligands were prepared by condensation of diamine and the corresponding beta-diketone. Copper(II) and nickel(II) complexes with chelate ligands containing ethane-1,2-diamine or prop...

2013
Pei Wang Lijun Xi Peipei Liu Yi Wang Wei Wang Ying Huang Weiming Zhu

Five new diketopiperazine derivatives, (3Z,6E)-1-N-methyl-3-benzylidene-6-(2S-methyl-3-hydroxypropylidene)piperazine-2,5-dione (1), (3Z,6E)-1-N-methyl-3-benzylidene-6-(2R-methyl-3-hydroxypropylidene)piperazine-2,5-dione (2), (3Z,6Z)-3- (4-hydroxybenzylidene)-6-isobutylidenepiperazine-2,5-dione (3), (3Z,6Z)-3-((1H-imidazol-5-yl)-methylene)-6-isobutylidenepiperazine-2,5-dione (4), and (3Z,6S)-3-b...

2009
S. Nirmala K. Karthikeyan E. Theboral Sugi Kamala L. Sudha P. T. Perumal

In the title compound, C(24)H(25)N(3)O(4), the pyrrolidine ring adopts an envelope conformation while the pyrrolidine-2'',5''-dione ring adopts a twist conformation. The indoline unit is planar [maximum deviation of -0.050 (9) Å] and forms a dihedral angle of 40.36 (4)° with the methoxy-phenyl ring. Intra-molecular C-H⋯O hydrogen bonds are observed. In the crystal, mol-ecules are linked into a ...

Journal: :Revista de la Facultad de Ciencias 2023

Linear and nonlinear properties of isoindoline-1,3-dione-fullerene-isoindoline-1,3-dione with the five phases were studied. The geometries combination attained using density functional theory DFT/B3LYP/6-31G+(d,p). calculated are static polarizability, anisotropy polarizability first hyperpolarizability at equilibrium geometry. In this article, theoretical design NLO molecules is discussed. res...

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