Phenylketonuria (PKU) was the first inherited metabolic disease in which dietary treatment was found to prevent the disease's clinical features. Treatment of phenylketonuria remains difficult due to progressive decrease in adherence to diet and the presence of neurocognitive defects despite therapy. This review aims to summarize the current literature on new treatment strategies. Additions to t...

Phenylalanine aminomutases (PAMs) are 4-methylideneimidazol-5-one (MIO)-dependent enzymes that catalyze the isomerization of (S)-a-phenylalanine to give (S)or (R)-bphenylalanine, which are precursors in the biosynthesis of various natural products. Several related tyrosine aminomutases (TAMs) have also been characterized. Furthermore, the mechanistically related MIO-dependent phenylalanine, tyr...

The herbicide glyphosate, N-(phosphonomethyl)glycine, induced phenylalanine ammonia-lyase (PAL) activity in the roots of dark-grown maize seedlings. This enzyme induction was shown to precede glyphosate-reduced fresh weight gain in the roots by 24--48 h. Feeding aromatic amino acids with glyphosate further inhibited growth while slightly lowering glyphosate-enhanced PAL activity. Soluble protei...

Carnation (Dianthus caryophyllus L.) is one of the most important cut flowers in the world. This experiment was carried out to evaluate the effects of pre-harvest application of some amino acids and organic acids on enzymatic traits and longevity of carnation flowers (Dianthus caryophyllus cv. Tessino) based on completely randomized design with 13 treatments and three...

Freshly harvested tomato fruit (Solanum lycopersicum) were pre-treated with 0, 50, and 100 µM prohexadione-calcium (Pro-Ca) and then stored at 1 °C for 21 days to investigate the effect of Pro-Ca treatment on electrolyte leakage (EL), malondialdehyde (MDA), proline and total phenols contents, and activity of phenylalanine ammonia-lyase (PAL) in relation to chilling injury (CI).Treatment with Pr...

Protein S-nitrosylation, the covalent binding of nitric oxide (NO) to protein cysteine residues, is one of the main mechanisms of NO signaling in plant and animal cells. Using a combination of the biotin switch assay and label-free LC-MS/MS analysis, we revealed the S-nitroso-proteome of the woody model plant Populus x canescens. Under normal conditions, constitutively S-nitrosylated proteins i...

abstract in this study the effect of combination of trichoderma harzianum bi and salicylic acid were studied on root knot nematode (meloidogyne javanica) disease on tomato under green house conditions. the roots of tomato seedlings at six-leaf stage were inoculated with suspensions of fungal antagonist (106 conidia/ ml), 5mm salicylic acid and 2000 second-stage juvenile (j2). combined applicati...