3-mercapto-1,2,4 benzotriazine (1) was methylated by methyl iodide in the presence of base to afford 1,2-dihydro-3-methyhercapto-1, 2,4 benzotriazine (2). the latter was reacted with hydrazine hydrate to give the corresponding 3-hydrazine derivative (3). compound (3) on condensation with phenacyl bromide gave 3- phenacyl hydrazino l,2,4-benzotriazine (4). ppa cyclization of the ketone (4) yield...

Density functional theory calculations were applied to study four previously published metal-catalyzed [2,3]-rearrangements from onium ylide intermediates, in pursuit of generalizations about when,...

In this paper, the chemical Functionalization of Carboxylate multi-walled carbon nanotubes by methyl (triphenyl phosphoranylidene) acetate have been investigated. Phosphorus Ylides are important compound in organic chemistry. At first, methyl (triphenyl phosphoranylidene) acetate, synthesized from salt metod in two steps: the formation of the phosphonium salt and the deprotonation of the latter...

The reaction mechanism for the conversion of methanol to hydrocarbons using zeolite catalysts is discussed. In particular, the mechanism of the formation of the initial carbon–carbon bond is considered in terms of the reaction of a surface ylide intermediate with adsorbed methanol. It is suggested that the formation of the initial carbon–carbon bond involves the interaction of the surface-bound...

An efficient procedure for 2-aroylbenzofuran preparation from 2-bromophenols, phenacyl bromides and paraformaldehyde is described. The cheap and stable paraformaldehyde served as the carbon source via an in situ formylation reaction.

SYNTHESIS AND EVALUATION OF NOVEL PHENACYL BASED CARBOXAMIDE DERIVATIVES OF PIPERIDINE AS ANTIHYPERTENSIVE AGENTS Shamim Akhtar, Z S Saify, M Arif, Nousheen Mushtaq, Ahsana Dar, Ashfaq Ahmed Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan, *Department of Pharmacology, HEJ Research Institute of Chemical Sciences, University of Karachi, ...

The synthesis of 3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydropyrazolo[5,4-b] pyrimidino[5,4-e]pyridine-5-one (6) was achieved by two different one-pot multi-component synthesis (one-pot three-component and one-pot four component synthesis). Mono and dialkylation of 6 under different conditions gave compounds 7-11. The hydrazine 12 produced from reaction of 9 with N₂H₄ was subjected to reac...