The Solar Vector Magnetograph (SVM) is a modern imaging spectropolarimeter installed at Udaipur Solar Observatory (USO). Earlier phases saw the development of the instrument using off-the-shelf components with in-house software development. Subsequently, improvements were done in the opto-mechanical design of the sub-systems and the telescope tracking system. The third phase of the instrument d...

Excretion into bile is well recognized as a major pathway for the elimination of amphipathic, hydrophobic, high molecular weight xenobiotics and thus complements the renal elimination of hydrophilic compounds of low molecular weight. For many xeno-biotics, excretion in bile, which has been termed a phase III elimination reaction (1), begins with an oxidation reaction (phase I), followed by conj...

The overall objective of the Cornell University TIPSTER Project was to improve end-user efficiency in information retrieval systems by reducing the amount of text that the user must process [1]. The project focuses on high precision IR, near-duplicate detection and context-dependent summarization. The two main foundations of the research are the latest version of the Smart system for informatio...

Phase III randomized controlled trials (RCT) in oncology fail to lead to registration of new therapies more often than RCTs in other medical disciplines. Most RCTs are sponsored by the pharmaceutical industry, which reflects industry's increasing responsibility in cancer drug development. Many preclinical models are unreliable for evaluation of new anticancer agents, and stronger evidence of bi...

This study was performed to obtain a comprehensive overview of the benefits and risks of second-line irinotecan monotherapy for advanced colorectal cancer. The literature was systematically reviewed to identify phase II and phase III trials that investigated the effect of second-line monotherapy with irinotecan. Thirty studies were included in this review: 25 phase II studies including 32 sampl...

The purpose of this study was to assess the impact of phase II dose-selection strategies on the likelihood of success of phase III clinical programs, comparing both traditional and adaptive approaches. We evaluated the impact of the phase II approach to dose selection (including traditional, design-adaptive, and analysis-adaptive approaches), the sample size used in phase II, the number of dose...

The aim of this study was to determine to what extent human migrating motor complex (MMC)-related secretory phenomena are influenced by a recently discovered period of duodenal retroperistalsis during late phase III. A constant-flow perfusion technique was used to measure gastric appearance of acid, bicarbonate, pepsin, bilirubin, IgA, and duodenally infused [14C]polyethylene glycol (PEG) 4000 ...

Efficient development of targeted therapies that may only benefit a fraction of patients requires clinical trial designs that use biomarkers to identify sensitive subpopulations. Various randomized phase III trial designs have been proposed for definitive evaluation of new targeted treatments and their associated biomarkers (eg, enrichment designs and biomarker-stratified designs). Before proce...