Aluminum plastic foamed mask package is commonly used for the packaging of tablets in the pharmaceutical companies and defective tablets can be produced during the production of the packaging. This paper studies several key algorithms of defect detection for tablets in aluminum and plastic package and designs the autodetection software which applies an image processing and recognition technolog...

28 29 The pharmacokinetics of raltegravir (RAL) in HIV patients is characterised by high 30 inter/intra-patient variability. We investigated the potential contribution of the drug 31 pharmaceutical formulation on RAL pharmacokinetics. 32 We firstly compared in vivo the pharmacokinetics of RAL from 67 patients in which 33 the drug was administered by swallowing the intact tablet with those obtai...

INTRODUCTION1, 2 In the last decade, interest in developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form (bi-layer tablet) has increased in the pharmaceutical industry, promoting patient convenience and compliance. Bi-layer tablets can be a primary option to avoid chemical incompatibilities between APIS by physical separation, and to enable the de...

OBJECTIVE Branding medication with a known pharmaceutical company name or product name bestows on the drug an added assurance of authenticity and effectiveness compared to a generic preparation. This study examined the impact of brand name and generic labeling on medication effectiveness and side effects. METHOD 87 undergraduate students with frequent headaches took part in the study. Using a...

The presence of a degradation product of alprazolam tablets that emerged throughout a short-stability assay has been determined and properly characterized. For this purpose an efficient methodology has been successfully applied, including SPE and HPLC methods for isolation and purification, respectively. LC/MS, MS/MS, 1H NMR, 13C NMR, UV and IR have been employed for structural elucidation conf...

A real-time THz color scanner has the potential to further expand the application scope of THz spectral imaging based on its rapid image acquisition rate. We demonstrated three possible applications of a THz color scanner in the biomedical field: imaging of pharmaceutical tablets, human teeth, and human hair. The first application showed the scanner's potential in total inspection for rapid qua...

As one of the commonly-used solid dosage forms, pharmaceutical tablets have been widely used to deliver active drugs into the human body, satisfying patient's therapeutic requirements. To manufacture tablets of good quality, diluent powders are generally used in formulation development to increase the bulk of formulations and to bind other inactive ingredients with the active pharmaceutical ing...

Due to various advantages such as high-precision dosing, manufacturing efficiency and patient compliance helped making tablets the most popular dosage forms among all available dosages forms. Compaction, which is an essential manufacturing step in the manufacture of tablets, mainly includes compression (i.e. reduction of volume of the powder under consideration and particle rearrangement) and c...

We present terahertz pulsed imaging (TPI) as a novel tool to quantify the hardness and surface density distribution of pharmaceutical tablets. Good agreement between the surface refractive index (SRI) measured by TPI and the crushing force measured from diametral compression tests was found using a set of tablets that were compacted at various compression forces. We also found a strong correlat...

In accordance with the International Pharmaceutical Excipients Council (IPEC), excipients are any component used during production procedure or included in a finished medicinal formulation but which is not an active ingredient prodrug. The USP-NF defines Forty different types of additives for usage medicines. Another classes, organoleptic compliance, gives medicines flavor and color. Medicine m...