A simple, sensitive and rapid reverse phase high performance liquid chromatographic method was developed for the estimation of Letrozole (Let) in bulk and pharmaceutical dosage forms. A Gemini C18 phenomenex column (250x4.6mm, 5μ) was used with a mobile phase containing a mixture of Acetonitrile and water in the ratio of 50:50. The flow rate was 1.1ml/min and effluents were monitored at 265nm a...

Purpose: To develop a simple, rapid and selective method for the spectrophotometric determination of cefadroxil and ceftriaxone using 1, 2napthaquinone-4sulfonic acid sodium. Methods: The method was based on the derivatization of cefadroxil and ceftriaxone with 1, 2naphthaquinone-4sulfonic acid sodium in alkaline medium to yield orange-colored products. Results: The reaction products of cefadro...

The gastrointestinal transit of pharmaceutical dosage forms has been measured in 201 studies in normal subjects using gamma scintigraphy. Solutions, small pellets, and single units (matrix tablets and osmotic pumps) were administered with different amounts of food in the stomach, ranging from fasted state to heavy breakfast. Gastric emptying was affected by the nature of the dosage form and the...

The objective of a medicinal formulation development project is to deliver drug to the patient in the required amount, at the required rate, consistently within a batch, from batch to batch, and over the product’s shelf life. To produce a drug substance in a final dosage form requires pharmaceutical ingredients. In selecting excipients for pharmaceutical; dosage forms and drug products the deve...

Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...

A fluorimetric method has been developed for the quantitative analysis of cefuroxime, based upon the formation of a fluorescent derivative formed by alkaline hydrolysis with 1.0 M sodium hydroxide and heating at 100 degrees C for 60 min. The fluorescent product gave excitation and emission maxima at 380 and 436 nm, respectively. The method was performed in aqueous solution adjusted to pH 10.5 b...

In the current conditions of pharmaceutical industry development segmentation available dosage forms among 13898 medicines registered on territory Ukraine allows to optimize provision population. Aim. To comprehensively analyze in Ukraine. Materials and methods. The study material was data State Register Medicines 2022. research methods used were frequency content analysis. Results discussion. ...