Tetrapods have two pairs of limbs, each typically with five digits, each of which has a defined number of phalanges derived from an archetypal formula. Much progress has been made in understanding vertebrate limb initiation and the patterning processes that determine digit number in developing limb buds, but little is known about how phalange number is controlled. We and others previously showe...

Acrodermatitis continua of Hallopeau (ACH) is a rare variant acral pustular psoriasis, exclusively involving the distal phalanges and nails hands feet. We herein report case concurrent ACH psoriatic arthritis sine psoriasis presenting with dactylitis. The patient was successfully treated biologics apremilast.

Symptomatic Disease Bone disease in its florid form, osteitis fibrosa cystica generalizata, is now rarely seen. In 1947 Norris (1) found an incidence of this condition of 91% in those with a parathyroid adenoma. The earliest changes can be detected by X-rays of the hands where subperiosteal erosions can be detected in the phalanges (especially radial aspect of the middle phalanges) and terminal...

Radiographs of the hands of 36 rock climbers were compared with radiographs of the hands of controls matched for age and sex. Subchondral cysts were present in the hands of 17 climbers and only two controls. Osteophytes or bony spurs were present in 14 climbers but not in any of the controls, and the only two cases of frank osteoarthrosis were in the hands of climbers. Cortical thickness of the...

Osteopoikilosis (OPK) or osteopathia condensans disseminate or spotted bones is a benign osteosclerotic dysplasia of unknown origin. It is an inherited autosomal disorder. It is usually detected as a coincidental finding at radiographic examination. Both sexes are equally affected. The condition is usually asymptomatic. The most common localization of these lesions is in the phalanges of the ha...

This patient was a Hindoo, 22 years of age. Description of the deformity.?The bones of the second and third toes of the left foot are very much enlarged. Each toe measures three inches in length and two and a half inches in circumference. The terminal phalanges are slightly curved towards one another, giving the part a claw-like appearance. The metatarsal bones are enlarged proportionately to t...

SPG (Symmetrical peripheral gangrene) is defined as symmetrical distal ischemic damage at two or more sites in the absence of large vessels obstruction. It has been ascribed to a number of infectious and non infectious conditions including connective tissue, cardiovascular, neoplastic and iatrogenic causes. We report a unique case of SPG in a 35-year-old Indian female who developed spontaneous ...