نتایج جستجو برای: ph responsive polymer
تعداد نتایج: 312864 فیلتر نتایج به سال:
Stimuli-responsive nanogels have gained signifi cant progress because of their great potential for applications in intelligent drug delivery and other biomedical fi elds. [ 1–4 ] Recently, much attention has been focused on the integration of stimuli-responsive polymer nanogels with inorganic nanoparticles (NPs) to combine the biosensing or bioimaging ability with the controlled drug delivery f...
The pKa of a polyelectrolyte has been determined experimentally by potentiometric titration and computed using Molecular Dynamics (MD) constant pH (CpH)methodology, which allows the pKa of each titratable site along the polymer backbone to be determined separately, a procedure which is not possible by current experimental techniques. By using experimental results within the CpHMD method, the si...
A nanostructured biocatalytic interface reversibly gating electrochemical reactions upon chemical signals processed by immobilized enzymes was architectured. The chemical signals were converted to local interfacial pH changes causing restructuring of the stimuli-responsive polymer and switching ON-OFF the electrochemical reaction.
Cancer metastasis is the leading reason for the high mortality of breast cancer. Herein, we report on a pH-responsive host-guest nanosystem of succinobucol (PHN) with pH-stimuli controlled drug release behavior to improve the therapeutic efficacy on lung metastasis of breast cancer. PHN was composed of the host polymer of β-cyclodextrin linked with multiple arms of N,N-diisopropylethylenediamin...
The present work reports the development of pH and enzyme dual responsive polysaccharide vesicular nano-scaffolds for the administration of doxorubicin via physical loading and polymer-drug conjugation to breast cancer cells. Dextran was suitably modified with a renewable resource 3-pentadecyl phenol unit through imine and aliphatic ester chemical linkages that acted as pH and esterase enzyme s...
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