BACKGROUND BAY 81-8973 is a full-length, unmodified, recombinant human factor VIII (FVIII) for the treatment of hemophilia A. OBJECTIVE The aim of this study was to compare the pharmacokinetic (PK) profile of BAY 81-8973 with antihemophilic factor (recombinant) plasma/albumin-free method (rAHF-PFM) PATIENTS/METHODS: In this phase I, open-label, crossover study, men aged 18-65 years with sever...

In this paper we discuss an application of CMOS photo-sensor array chip using pulse frequency modulation (PFM) to sub-retinal implantation to recover human vision. PFM with integration mode as photo-sensing circuit is used to realize enough dynamic range and compatibility with signals in real retina. To effectively stimulate the retinal cells, we have designed a PFM circuit with limited bandwid...

The frequency dependence of the phase field model(PFM) is studied. A simple PFM is proposed, and is tested in a laminar boundary layer. The Blasius’s laminar boundary layer solution on a flat plate is used for the flow pattern, and several frequencies are imposed on the PFM, and the decay times of the interfaces are obtained. The computations were conducted for three cases: 1) no-flow, and 2) a...

The photonic force microscope (PFM) is an opto-mechanical technique that uses an optically trapped probe to measure forces in the range of pico to femto Newton. For a correct use of the PFM, the force field has to be homogeneous on the scale of the Brownian motion of the trapped probe. This condition implicates that the force field must be conservative, excluding the possibility of a rotational...

[Purpose] The purpose of this this study was to examine the immediate effects of intervention of proprioceptive neuromuscular facilitation (PNF), neuromuscular joint facilitation (NJF) and NJF+pelvic floor muscle (PFM) exercise. [Subjects] Thirteen young people (5 males, 8 females) who had chronic low back pain on one side for more than 6 months. [Methods] Subjects were asked to lie on their si...

Hypothesis / aims of study The pelvic floor muscle training (PFMT) has been indicated for treatment of pelvic floor dysfunction, with A level of evidence for the urinary incontinence (1). Recently, the indirect training of pelvic floor muscles (PFM) by transversus abdominis (TrA) muscle contraction has been suggested as a new method for strengthening PFM (2), and the hypopressive exercises reco...

We demonstrate an approach for probing nonlinear electromechanical responses in BiFeO(3) thin film nanocapacitors using half-harmonic band excitation piezoresponse force microscopy (PFM). Nonlinear PFM images of nanocapacitor arrays show clearly visible clusters of capacitors associated with variations of local leakage current through the BiFeO(3) film. Strain spectroscopy measurements and fini...

Pseudomonas syringae pv. actinidiae (Psa) and Pseudomonas syringae pv. actinidifoliorum (Pfm) are closely related pathovars infecting kiwifruit, but Psa is considered one of the most important global pathogens, whereas Pfm is not. In this study of Actinidia deliciosa 'Hayward' responses to the two pathovars, the objective was to test whether differences in plant defense responses mounted agains...