Malignant transformation of tumor accompanies profound changes in the normal neighboring tissue, called tumor stroma. The tumor stroma provides an environment favoring local tumor growth, invasion, and metastatic spreading. Nuclear imaging (PET/SPECT) measures biochemical and physiologic functions in the human body. In oncology, PET/SPECT is particularly useful for differentiating tumors from p...

The ever-growing need for radiopharmaceuticals, i.e., compounds containing pharmaceutical drugs and radioisotopes used medical diagnostic imaging (SPECT/PET scan) treating neoplasms, is significantly leading to an increased demand such substances in hospitals clinics worldwide. Currently, most large-scale productions of required radiopharmaceuticals are carried out research reactors, via the fi...

Imaging plays an important role in prostate cancer (PC), including accurate evaluation of the extent of disease, assessment of sites of recurrent disease, and monitoring of response to treatment. Molecular imaging techniques are among the novel developments related to the imaging of PC, and various SPECT and PET radiopharmaceuticals are now available in clinical trials or commercially. Here we ...

(68)Ga represents one of the very early radionuclides applied to positron emission tomography (PET) imaging at a time when even the wording PET itself was not established. Today it faces a renaissance in terms of new (68)Ge/(68)Ga radionuclide generators, sophisticated (68)Ga radiopharmaceuticals, and state-of-the-art clincial diagnoses via positron emission tomography/computed tomography (PET/...

Positron emission tomography (PET) is a nuclear medicine technique that provides tomographic images of the distribution of positron-emitting radiopharmaceuticals. We have previously proposed a method for estimating an input blood curve based on a standard independent component analysis using a specially designed cost function and a preprocessing scheme. While the input blood curve was successfu...

The development of noninvasive imaging techniques using monoclonal antibodies (mAbs) is a quickly evolving field. Immuno-PET uses positron-emitting isotopes to track the localization of mAbs with excellent image quality. Procedures for labeling mAbs with (89)Zr or (124)I using good manufacturing procedures have been established, and therefore these radiopharmaceuticals are being investigated fo...

Nuclear Medicine examinations are integral in the management of children with cancer. Imaging with conventional gamma camera systems, hybrid gamma camera systems and radiopharmaceuticals; and with positron emission tomography (PET) and PET/ CT systems and positron emitters can be used for staging, metastatic work-up, surveillance follow-up, therapeutic response assessment and treatment. Tumors ...

Positron Emission Tomography (PET) is a method for measuring biochemical and physiological processes in vivo in a quantitative way by using radiopharmaceuticals labelled with positron emitting radionuclides such as C, N, O and F and by measuring the annihilation radiation using a coincidence technique. This includes also the measurement of the pharmacokinetics of labelled drugs and the measurem...