Peroxisome proliferators cause liver cell proliferation in addition to other pleiotropic effects such as peroxisome proliferation and induction of certain peroxisomal and cytosolic enzymes in liver. Since dexamethasone has been shown to inhibit mitogen-induced liver cell hyperplasia, we examined whether dexamethasone inhibits only cell proliferation without affecting peroxisome proliferation in...

The peroxisome proliferator activated receptor a (PPAR) is a member of the steroid/hormone receptor superfamily that mediates the peroxisome proliferator-dependent transcriptional activation of genes encoding several peroxisomal and microsomal enzymes as well as peroxisome proliferation. Human liver is refractory to the pathological effects of peroxisome proliferators that are seen in mice. Wit...

Solution- and solid-phase methods for the preparation of peptide-substituted thiazolidinediones have been developed as an approach towards the preparation of a library of these compounds as potential ligands for the peroxisome proliferator-activated receptors (PPARs).

Background: Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The aim of this study was to explore the effect of resveratrol (RES) on Canonical β-catenin/Wnt and forkhead box O (FOXO) pathways in CAD patients.Method: We performed this study on 10 metabolic syndrome patients with three-vessel CAD and 10 sex-aged matched healthy subjects. The effects of RES on...

Background: Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The aim of this study was to explore the effect of resveratrol (RES) on Canonical β-catenin/Wnt and forkhead box O (FOXO) pathways in CAD patients.Method: We performed this study on 10 metabolic syndrome patients with three-vessel CAD and 10 sex-aged matched healthy subjects. The effects of RES on...

1Vascular Biology Program, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA 2Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA 3Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, AB, Canada T2N 4N1 4 Institute for Biocomplexity and Informatics, University of Calgary, Calgary, AB, Ca...

Background: Peroxisome proliferator-activated receptors (PPARs) have a pivotal role in regulating genes that are involved in lipid