Hydrotropy refers to increasing the water solubility of otherwise poorly soluble compound by the presence of small organic molecules. While it can certainly increase the apparent solubility of a lipophilic drug, the effect of hydrotropy on the drugs' permeation through the intestinal membrane has not been studied. The purpose of this work was to investigate the solubility-permeability interplay...

A 3D model of oil and gas fields is important for reserves estimation, for cost effective well placing and for input into reservoir simulators. Reservoir characterization of permeability, litho-facies and other properties of the rocks is essential. A good model depends on calibration at the well locations, with cored wells providing the best data. A subset of wells may contain specialized infor...

The purpose of this study was to investigate the impact of oral cyclodextrin-based formulation on both the apparent solubility and intestinal permeability of lipophilic drugs. The apparent solubility of the lipophilic drug dexamethasone was measured in the presence of various HPβCD levels. The drug's permeability was measured in the absence vs. presence of HPβCD in the rat intestinal perfusion ...

By analyzing the permeability controlling factors of tight sandstone reservoir in Wuhaozhuang Oil Field, the permeability is considered to be mainly controlled by porosity, clay content, irreducible water saturation and diagenetic coefficient. Because the conventional BP algorithm has its drawbacks such as slow convergence speed and easy falling into the local minimum value, an improved three-l...

Abstract This paper presents a numerical solution to optimize RTM processes based on DDDAS methodology, taking permeability as stochastic. The model proposed in this investigation allows real-time accurate prediction of the filling rate by adjusting parameters with on-line captured process data. suitability was tested and validated under different variations like pressure preform permeability.

Here we examine the consequences of uncertainty with respect to geological parameters, using large-scale 2D models. We also investigate ways to reduce prediction uncertainty, either by showing how a parameter’s influence is negligible for a given project design, or by showing for which parameters additional data will significantly increase the quality of prediction. TOUGH2/ECO2N is used to simu...