The topical delivery of non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. Ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. However, it i...

     The topical delivery of non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. Ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. However, it i...

The two parameters usually invoked when discussing transport across membranes are the "diffusion permeability coefficient" and the "hydrodynamic permeability coefficient." In this study the magnitude of these two coefficients is established experimentally for collodion membranes of differing porosities. The hydrodynamic permeability is predominant while convergence of the two permeabilities ten...

In this study, the long-term tailing derived from the storage process of contaminants in low-permeability zones is investigated. The release from these areas in the groundwater can be considered a long-term source that often undermines remediation efforts. An Image Analysis technique is used to analyze the process and evaluate the concentrations of a tracer at different points of the test secti...

Trans-epithelial tracer urea flux across Madin-Darby canine kidney (MDCK) cells permanently expressing the urea transporter UT-A1 is stimulated by agents that activate the cAMP signaling pathway, such as vasopressin or forskolin, thus mimicking the activation of urea permeability in the inner medullary collecting duct in the presence of vasopressin. Here, we report that UT-A1-mediated urea flux...

The reduction of membrane potential in frog sartor/us muscle produced by rubidium and cesium ions has been studied over a wide concentration range and compared with depolarization occasioned by potassium ions. The constant field theory of passive flux has been used to predict the potential changes observed. The potential data suggest certain permeability coe~eient ratios and these are compared ...

The reduction of membrane potential in frog sartorius muscle produced by rubidium and cesium ions has been studied over a wide concentration range and compared with depolarization occasioned by potassium ions. The constant field theory of passive flux has been used to predict the potential changes observed. The potential data suggest certain permeability coefficient ratios and these are compare...

Background Compared to high-flux dialysis membranes, novel medium cut-off (MCO) membranes show greater permeability for larger middle molecules. Methods In two prospective, open-label, controlled, randomized, crossover pilot studies, 39 prevalent hemodialysis (HD) patients were studied in four dialysis treatments as follows: study 1, three MCO prototype dialyzers (AA, BB and CC with increasin...