BACKGROUND Studies have shown that the concentration of interleukin (IL)-6 in peritoneal fluid is increased in patients with endometriosis; however, whether the disorders involving IL-6 contribute to the development of endometriosis is still unclear. In the present study, we evaluated the potential role of IL-6 and IL-6 receptor (IL-6R) in the pathogenesis of endometriosis. MATERIAL AND METHODS...

Background: Chemokines, proteins that operate within the body's immune system, play numerous roles in menstruation, bacterial infection, implantation of embryos, and the maintenance of early pregnancy. They are also strongly related to the pathogenesis of endometriosis. Materials and Methods: This is review article that were indentifical by computer search of MEDLINE (1984- 2013). Results:...

The pathophysiology of (deep) endometriosis is still unclear. As originally suggested by Cullen, change the definition "deeper than 5 mm" to "adenomyosis externa." With the discovery of the old European literature on uterine bleeding in 5%-10% of the neonates and histologic evidence that the bleeding represents decidual shedding, it is postulated/hypothesized that endometrial stem/progenitor ce...

BACKGROUND/AIMS The neural cell adhesion molecule L1CAM is a transmembrane glycoprotein abnormally expressed in tumors and previously associated with cell proliferation, adhesion and invasion, as well as neurite outgrowth in endometriosis. Being an attractive target molecule for antibody-based therapy, the present study assessed the ability of the monoclonal anti-L1 antibody (anti-L1 mAb) to im...

Endometriosis is a condition where tissue similar to the endometrial stroma or glands is found in locations outside the uterus. The disease generally affects women during their reproductive years (more commonly in their 40s or 50s) and involves 7-10% of the female population (1) . Among women who undergo a diagnostic laparoscopy for infertility the prevalence of endometriosis is 20-50% (2-3) . ...

Aim Peritoneal endometriosis is a chronic inflammatory disease particularly associated with macrophages. Of note, adipose tissues fibrotic changes in the context of peritoneal endometriotic lesions are often observed during surgery. However, characteristics still unknown. In this study, we investigated status retroperitoneal adjacent to pelvic lesions. Methods Thirty-two patients who underwent ...

s:865:"We read with interest the manuscript entitled "Serum and peritoneal fluid levels of vascular endothelial growth factor in women with endometriosis" recently published in the International Journal of Fertility and Sterility (1). The authors measured the levels of vascular endothelial growth factor in serum and peritoneal fluid of 179 women, 90 of whom were diagnosed with endometriosis, an...

Diaphragmatic endometriosis is a rare entity, often asymptomatic, which has been described only in small series. It is almost always associated with severe pelvic involvement. The most plausible theory about this condition is based on retrograde menstruation and subsequent transportation of viable cells in peritoneal fluid from the pelvis up the right gutter to the right hemidiaphragm, thus dem...

BACKGROUND Intestinal endometriosis is a common benign disease among menstruating women that affects the intestinal tract. CASE PRESENTATION This case report presents seven Japanese cases of intestinal endometriosis with colorectal cancer treated by laparoscopic surgery. Five of the seven cases reported here are women presenting with bowel obstruction due to colorectal endometriosis with colo...

SUMMARY Infertility has a special importance in gynecology in causing social, psychological and somatic prohlems. Endometriosis is a benign but progressive disorder in reproductive life and is more common in infertile women. CA 125 is a cell membrane glycoprotein. The endometrium is one the known source of this antigen and seems to be elevated in the pelvic endometriosis. In this study, from...