BACKGROUND Malignant peripheral nerve sheath tumors are rare tumor entities that originate from peripheral nerve sheaths and have an unfavorable prognosis. Metastatic spread to the cerebral parenchyma is absolutely rare. This case report describes the clinical course in a 60-year-old man whose tumor came to medical attention because of a seizure. CASE PRESENTATION Magnetic resonance imaging d...

We present the case of a malignant peripheral nerve sheath tumour (MPNST) that developed on the upper lip of an 86 year old woman. MPNSTs are highly aggressive sarcomas that very rarely occur in the face. We know of no other reported cases of a malignant peripheral nerve sheath tumour arising from the upper lip.

Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma arising from neuroectoderm-derived cells comprising the outer coverings of peripheral nerves. Given the diverse cell types comprising the peripheral nerve sheath, both benign and malignant nerve sheath tumors display a wide range of histologic appearances. MPNST can arise either in association with proximal nerve trun...

By using the D2-40 antibody, we have observed podoplanin expression in Schwann cells and perineurial cells. Podoplanin expression has not been well characterized in peripheral nerve sheath tumors. Because neoplasms of neural crest lineage, including peripheral nerve sheath and melanocytic neoplasms, may share histologic and immunohistochemical characteristics, we evaluated podoplanin and S-100 ...