Hemangiomas of the median nerve are extremely rare; only 12 cases have been reported in the literature. We discuss a patient who presented with paresthesia and pain along the distribution of the left median nerve secondary to a cavernoma of the proximal part of the nerve as suspected on MRI scan. Total removal of the mass was achieved with immediate relief of the symptoms and no neurologic defi...

background: axotomy causes sensory neuronal loss. reconnection of proximal and distal nerve ends by surgical repair improves neuronal survival. it is important to know the morphology of primary sensory neurons after the surgical repair of their peripheral processes. methods: animals (male wistar rats) were exposed to models of sciatic nerve transection, direct epineurial suture repair of sciati...

Introduction: Schawannomas (neuromas, neurilemmomas) are benign tumors originating from showann cells or nerve fiber sheet cells. They are solitary, encapsulated tumors usually attached to, or surrounded by a nerve. Case Report: We present a case of left hypoglossal nerve schwannoma in a 19 year old man who was admitted with progressive left tongue atrophy. Conclusion: Schwannoma of the hy...

Despite the important role of both cyclooxygenase (COX) isoforms (i.e. COX-1 and COX-2) in maintenance of hypersensitivity following peripheral nerve injury, their role in the development of neuropathic pain is not clear. The present study was undertaken to determine the effect of COX inhibitors to address the potential role of COX isozymes in the development of neuropathic pain in rats after c...

background:   valproic acid (vpa) is used to be an effective anti-epileptic drug and mood stabilizer. it has recently been demonstrated that vpa could promote neurite outgrowth, activate the extracellular signal regulated kinase pathway, and increases bcl-2 and growth cone-associated protein 43 levels in spinal cord. in the present research we demonstrate the effect of vpa on peripheral nerve r...

Nerve transfers for peripheral nerve injuries have become increasingly popular over the past two decades. While techniques ulnar repair been well-documented, more recent median and radial branch reinnervation are still being explored. This review describes outcomes of common emerging distal branches nerves.

a malignant peripheral nerve sheath tumor (mpnst) is very rare, representing 3 - 10% of all soft tissue sarcomas. approximately half of all such tumors are diagnosed in patients with neurofibromatosis type 1 (nf1). the extremities are involved most commonly, and the patient’s age is usually 20 - 50 years. herein, we present a case of an mpnst that developed sporadically in an unusual location a...

background: bone marrow and umbilical cord stromal cells are multipotential stem cells that have the ability to produce growth factors that play an important role in survival and generation of axons. the goal of this study was to evaluate the effects of the two different mesenchymal stem cells on peripheral nerve regeneration. materials and methods: in this experimental study, a 10 mm segment o...

Leprosy is a chronic infectious disease endemic in Iran that mainly involves skin and peripheral nerves. Leprosy has several clinical forms. One of them is “Pure neural leprosy”. The diagnosis of this form is delayed due to lack of clinical signs in other tissues and can lead to permanent deformity. I will discuss my experience for 20 years in the diagnosis and treatment of this form of leprosy...