نتایج جستجو برای: perforin gene
تعداد نتایج: 1142550 فیلتر نتایج به سال:
Vitiligo is an autoimmune skin disorder clinically characterized by depigmented patches. With therapeutically challenging, a deeper understanding of its pathomechanisms needed to improve current therapeutic approaches. Granzyme B (GzmB), serine protease, has been identified in abundance vitiligo lesions, and genetic polymorphisms GZMB have reported multiple patients. It initially discovered gra...
Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity. Perforin-2 is expressed constitutively in phagocytes and inducibly in parenchymal, tissue-forming cells. In vitro, Perforin-2 prevents the intracellular replication and proliferation of bacterial pathogens in these cells. Perforin-2 knockout mice are unable to control the systemic dissemination of methicil...
Perforin is an essential component in the cytotoxic lymphocyte-mediated cell death pathway. The traditional view holds that perforin monomers assemble into pores in the target cell membrane via a calcium-dependent process and facilitate translocation of cytotoxic proteases into the cytoplasm to induce apoptosis. Although many studies have examined the structure and role of perforin, the mechani...
Granzyme B and perforin are cytoplasmic granule-associated proteins used by cytotoxic T lymphocytes and natural killer (NK) cells to kill their targets. However, granzyme B gene expression has also been detected in a non-cytotoxic hematopoietic murine multipotent stem cell line, FDCP-Mix. The objective of the present study was to investigate whether granzyme B and perforin could be expressed in...
19 Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity. Perforin-2 is 20 expressed constitutively in phagocytes and inducibly in parenchymal, tissue-forming cells. In vitro, 21 Perforin-2 prevents the intracellular replication and proliferation of bacterial pathogens in these cells. 22 Perforin-2 knockout mice are unable to control the systemic dissemination...
background: perforin is known to be important in cytolytic activity mediated by natural killer (nk) cells. objective: to study the relationship between the efficiency of nk and lymphokine-activated killer (lak) cells activity, and the expression of perforin and hla class i molecules. methods: lak cells were generated by in vitro culturing of human peripheral blood lymphocytes (pbls) in the ...
Perforin-deficient [perforin (-/-)] mice were infected with two strains of JHM virus (JHMV) to analyze the role of perforin-mediated cytotoxicity in acute lethal and subacute central nervous system (CNS) infections. During both acute and subacute infections, the overall mortality of the perforin (-/-) mice was not different from that of the controls. Perforin (-/-) mice survived longer than the...
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