Many recognize the phrase attached to title “The Times They Are A-Changin’” as name of 1964 record album by folk singer Bob Dylan.1 That seems like an appropriate way describe new phase percutaneous coronary intervention (PCI) delivery in United States and reason for a expert consensus statement on PCI without on-site surgical backup Society Cardiovascular Angiography & Interventions (SCAI).2 I...

Objective: Lorazepam is a sedative that may be used for the management of anxiety, insomnia, and chemotherapy-induced nausea and vomiting. Lorazepam can be incorporated into transdermal bases such as Lipoderm, referred to as Phospholipid Base, for drug delivery across the skin. The purpose of this study is to characterize the percutaneous absorption of lorazepam 5 mg/g in Phospholipid Base, whe...

Preoperative embolization has played a major role in the devascularization of carotid body tumours prior to surgery. There are two currently approved methods to achieve this, which is a superselective transarterial endovascular embolization and a direct percutaneous injection of embolic materials . Superselective transarterial endovascular embolization has potential limitations especially in le...

Tacrolimus (FK506), an effective immunosuppressant for treating inflammatory skin diseases, hardly penetrates into and through the skin owing to its high hydrophobicity and molecular weight. The aim of this study was to develop a hybrid system based on nicotinamide (NIC) and nanoparticles (NPs) encapsulating FK506, such as FK506-NPs-NIC, for facilitating percutaneous delivery, which exploited v...

OBJECTIVES We report our animal experience of endovascular valve replacement (VR) of failed bioprosthesis (BP) using an original delivery catheter allowing repositioning of the valved stent (VS). BACKGROUND Among the different devices designed for percutaneous VR, none has the potential for repositioning of a fully deployed VS. METHODS Five sheep underwent, on beating heart, tricuspid VR wi...

In the modern era of interventional cardiology, stent delivery failure in complex, tortuous and/or calcific coronary anatomy is encountered in approximately 5% of cases, leading to incomplete revascularization and procedural failure. The GuideLiner® catheter (Vascular Solutions, MN, USA) is a monorail guide catheter extension that facilitates safe and effective delivery of balloons and/or stent...

Many new devices and techniques are being developed to attempt a reduction in embolic stroke risk for patients with atrial fibrillation who are either unable or unwilling to maintain long-term anticoagulation. One of these new devices (LARIAT®, SentreHEART Inc., Redwood City, California, USA) employs delivery of an epicardial suture to ligate the left atrial appendage after percutaneous pericar...

Fetal sacrococcygeal teratoma (SCT) is the most common tumor in the neonatal period and is easily detected by modern ultrasound techniques, mostly during the second-trimester screening. It can cause significant fetal/neonatal morbidity and mortality due to its size, vascular loading, possible rupture, and labor dystocia. Mostly cystic teratomas have favorable prognosis, but if untreated in uter...