introduction: scorpion venom is a source of bioactive peptides, and some antimicrobial peptides (amps) have been found in the venom gland of scorpions. therefore, the discovery of new anti-infective agents is an essential need to overcome the problem of antibiotic resistance of clinical isolates. here, we describe three new cationic amps, including meuvap-6, meuap-18-1, and meupep34 from the ve...

the possibility of chemical modification of peptides and proteins under the condition of proteolytic digestions and fabms analysis was investigated. the results ;indicate that among the amino acid constituents of peptides and proteins: serinefcysteine, and cystine are the most sensitive residues which undergo chemical modificadons under the exprimenta1 conditions. the chemical modification of t...

The intrinsic pathway of apoptosis is regulated by the Bcl-2 family proteins. Inhibition anti-apoptotic members represents a strategy to induce apoptotic cell death in cancer cells. We have measured membrane binding properties series peptides, including modified α/β-peptides, designed exhibit enhanced permeability allow entry and improved access for engagement members. peptide cargo based on pr...

Peptides have shown Promising effect as pharmaceutics with the potential to treat a widevariety of diseases. Peptides are mostly synthesized by biological technology or chemicalmethods. Solution phasepeptide synthesis (SPS) and solid phase peptide synthesis (SPPS) aretwo major chemical techniques for peptidesproduction.In this research, the synthesis ofdipeptde(β-alanine-L-histidine)wasexamined...

the major limitation in the application of bioactive molecule is their low permeation across plasma membrane. in 1988 it was discovered, that a natural polycationic protein, the trans-acting activator of transcription (tat) of the human immunodeficiency virus (hiv-1), passed very efficiently through cell membrane of cultured mammalian cells. tat became known as the first cell penetrating peptid...

purpose: to evaluate colostrum total protein differences between left and right breasts and between mothers of boy and girl infants. materials and methods: a cross sectional study for delivery was carried out on 30 boy-delivered and 30 girl-delivered mothers aged 16 to 36 years, conducted at the izadi and al-zahra hospitals in qom city, iran. colostrum was collected from both breasts by manual ...

scorpion venoms contain of variety of peptides toxic to mammals ، insects and crustaceans. toxic peptides are the main factors in scorpion venom causing toxicity, (their amount being 1-3%of total venom.). most of the scorpion toxins have been isolated from the venoms of scorpions in the family buthidae. the scorpion buthotus schach belonging to the buthidae family is widely found in the western...

Rheumatoid arthritis (RA) is associated with HLA-DRB1 genes encoding a five amino acid basic motive, the shared epitope SE). Each genotype defines specific risk of developing RA. RA preceded by emergence anti citrullinated protein antibodies (ACPAs). Citrullin neutral version arginin, acid, formed after post translational modification Peptidyl Arginyl Deiminases (PADs). are also ACPAs. Two mode...