a review of the publications in traditional medicine indicates that the root of glycyrrhiza glabra l., fabaceae, is recommended for treatment of epilepsy. as a renewable source, the leaves of g. glabra var. glandulifera growing in iran were examined for possible anticonvulsant activity. the anticonvulsant activity of the leaves’ ethanol extract and dichloromethane, f1, n-hexane, f1a, and methan...

background: an important role for oxidative stress, as a consequence of epileptic seizures, has been suggested. coriandrum sativum has been shown that have antioxidant effects. central nervous system depressant effects of c. sativum have also been reported. in this study, the effects of hydroalcoholic extract of aerial parts of the plants on brain tissues oxidative damages following seizures in...

Dopamine (DA) receptor supersensitivity was induced in albino rats by haloperidol (5 mg/kg, ip day, for 18 days) and after 48 hr carbamazepine (CBZ) was administered in graded doses. The animals were subjected to Maximal Electroshock Seizures (MES) test, Minimal Electroconvulsive Threshold (MET) test and Pentylenetetrazole (PTZ)-induced convulsions test. Haloperidol pretreatment marginally incr...

Treatment with Spinacia oleracea extract (SO; 400 mg/kg body weight) decreased the locomotor activity, grip strength, increased pentobarbitone induced sleeping time and also markedly altered pentylenetetrazole induced seizure status in Holtzman strain adult male albino rats. SO increased serotonin level and decreased both norepinephrine and dopamine levels in cerebral cortex, cerebellum, caudat...

We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-alpha) was proconvulsive in this respect. The present study shows that TNF-alpha, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that hi...

We studied the effects of high doses of pentobarbital (PB) and carbamazepine (CBZ) on electrolyte levels and pH in an epileptic animal model. Pentobarbital decreased Ca2+ and Na+ levels without pentylenetetrazole (PTZ). After this, Ca2+ and Na+ levels continued to decrease except when CBZ was used, which preserved the Ca2+ levels PTZ may have opposed effects on PB. Our results suggest that PB c...

A new series of 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles was designed and synthesized as anticonvulsant agents. Electroshock and pentylenetetrazole-induced lethal convulsion tests showed that the introduction of an amino group at position 2 of 1,3,4-oxadiazole ring and a fluoro substituent at ortho position of benzyloxy moiety had the best anticonvulsant activity. Our resul...

INTRODUCTION Epilepsy and seizures disorders affect 50 million people around the world and contribute to morbidity and mortality [1]. The use of antiepileptic drugs is limited due to the vast array of adverse effects. Such as cognitive impairment, effective disorders and recurring seizures [2]. Hence, there is a need for the development of new antiepileptic drugs with fewer adverse effects and ...