OBJECTIVE To evaluate pentoxifylline for the treatment of recurrent aphthous stomatitis. DESIGN A 60-day, randomized, double-blind, placebo-controlled trial with a 60-day no treatment follow-up. SETTING An oral medicine specialist referral center in Manchester. PARTICIPANTS Forty-nine volunteers who passed the initial assessment for recurrent aphthous stomatitis entered a pretrial phase i...

background: pentoxifylline might have a role in the suppression of inflammatory cytokines in non-alcoholic fatty liver disease (nafld).the aim of study  was  to evaluate the effect of pentoxifylline on liver function tests in non-diabetic subjects with nafld. materials and method: this clinical trial was performed in 120 nafld patients. they were divided to two groups by balance block randomiza...

OBJECTIVE To determine whether pentoxifylline 400 mg (Trental 400) taken orally three times daily, in addition to ambulatory compression bandages and dressings, improves the healing rate of pure venous ulcers. DESIGN Randomised, double blind placebo controlled trial, parallel group study of factorial design, permitting the simultaneous evaluation of alternative pharmaceutical, bandaging, and ...

BACKGROUND Recent trials have indicated a beneficial effect of pentoxifylline on measures of inflammation and markers of cardiac dysfunction in people with heart failure. However, it is uncertain whether pentoxifylline should be used routinely in the management of heart failure. OBJECTIVE To determine the effectiveness of pentoxifylline in heart failure. DESIGN Systematic review of randomis...

Objective(s):Pentoxifylline is an immunomodulatory and anti-inflammatory agent and is used in vascular disorders. It has been shown that pentoxifylline inhibits proinflammatory [d1] cytokines production. The purpose of this study was to investigate the therapeutic effects of pentoxifylline on the treatment of autoimmune diabetes in mice. Materials and Methods: Diabetes was induced by multiple l...

Cilostazol is a new phosphodiesterase inhibitor with anti-platelet and vasodilatory properties. Cilostazol and pentoxifylline are the only two drugs that have been approved for the treatment of patients with intermittent claudication. However, the mechanisms by which exercise tolerance is improved remain unclear. Vascular endothelial growth factor (VEGF) is a potent endothelial mitogen that res...

PURPOSE Alprostadil, a prostaglandin (PG)E(1) analogue and pentoxifylline, an alkylxanthine derivate, have been shown to exert vasodilatory effects in several vascular beds. The purpose of the present study was to investigate the effect of PGE(1) and pentoxifylline on the ocular circulation. METHODS A placebo-controlled, double-masked, three-way, crossover study was performed in 15 healthy ma...

Free radical formation in heme proteins is recognized as a factor in mediating the toxicity of many chemicals. The present study was designed to evaluate the dose-response relationship of the free radical scavenging properties of pentoxifylline in nitri te-induced Hb oxidation. Different concentrations of pentoxifylline were added at different time intervals of Hb oxidation in erythrocytes lysa...

INTRODUCTION Livedoid vasculitis is a painful ulcerative condition affecting the legs that is often difficult to treat. In this case series, the clinical profile of 6 patients with livedoid vasculitis and their treatment response to aspirin and pentoxifylline are reported. MATERIALS AND METHODS This is an open trial. Investigations to exclude secondary causes of livedoid vasculitis were done....

This study was conducted to determine whether pentoxifylline has an in vitro effect on sperm motion characteristics in normozoospermic men. The subjects of the study were 15 male volunteers. After the spermatozoa were washed with mBWW medium, the sperm suspension was divided into two aliquots: one was treated with 1 mg/ml pentoxifylline, the other was used as a control. The sperm motion charact...