(R)-(1)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 (CYP or P450) 2A6. Menthofuran caused a timeand concentration-dependent loss of CYP2A6 activity. The inactivation of CYP2A6 was characterized by a Ki of 2.5 mM and a kinact of 0.22 min 21 for human liver microsomes and a Ki of 0.84 mM and a kinact of 0.25 min 21 for purified expressed CYP2A6. Addition of...

In the current market, there is a growing interest in traditional herbal nutraceuticals. Therefore, formulations have re-emerged as products with sought-after nutraceutical and disease-preventing properties. The health-promoting effects of bioactives are attributed to active phytoconstituents these plants. Thus, aim present study was evaluate putative effectiveness preparations ten herbs (chamo...

the potato tuber moth (ptm), phthorimaea operculella zeller (lepidoptera: gelechiidae), is an important pest of potato and other solanaceous plants. it is cosmopolite and oligophage that exists in most countries where potatoes are grown. because of chemical treatment adverse effects, there is a necessity to find safe alternatives to synthetic insecticides. so, medicinal plants are promising sin...

abstract

Essential oils from mint plants, including peppermint and pennyroyal oils, are used at low levels as flavoring agents in various foods and beverages. Pulegone is a component of these oils. In a 2-year bioassay, oral administration of pulegone slightly increased the urothelial tumor incidence in female rats. We hypothesized that its mode of action (MOA) involved urothelial cytotoxicity and incre...

ABSTRACT Background: Herbal distillates have been used for many centuries as drinks, flavors, and herbal medicine in Iran, especially in the city of Urmia. Recently, some studies claimed the presence of methanol in different types of herbal distillates. Methanol is a highly toxic compound which can cause acute or chronic toxicity in humans. Acute poisoning with methanol can cause different co...

Two of the major factors that should be considered in leaves extraction are the solvent type and extraction method. In the current study, the effects of two solvents (Ethanol and Methanol) and two extraction methods (soaking and soxhlet) on phenolics and flavonoid contents, antibacterial and antiradical properties of extracts were investigated in a factorial experiment based on completely rando...

background: most of the population in the different areas of world is affected by bacterial infections responsible for dental caries. due to the importance of traditional medicines derived from herbs used for dental problems, this study investigated in vitro antibacterial activity of mentha longifolia essential oil from ardabil, iran, on streptococcus mutans, lactobacillus rhamnosus and actinom...