The aim of this study is to improve dissolution and bioavailability of poorly water soluble Efavirenz (Efv), a potent and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Its effectiveness can be attributed to its long half-life (t1/2) of 52–76 h after single dose. Formulation of poorly water soluble drug for oral delivery is one of the biggest challenges. Amongst the availabl...

C-phycocyanin from Spirulina platensis was purified in aqueous two-phase systems (ATPS) of polyethylene glycol (PEG)/potassium phosphate, varying the molar mass of the PEG. Results using a full factorial design showed that an increase in the concentration of salt and decrease in the concentration of PEG caused an increment in the purification factor for all the ATPS studied. Optimization of the...

Polyethylene glycol (PEG 4000), Browse Plus (BP), wood ash (WA) and boiling water were evaluated as tannin deactivation methods on tannins in Acacia nilotica fruits. Twenty four Matebele goats of mean body mass, 38.7 ± 3.12 kg, were used in a digestibility and nitrogen balance trial. A completely randomized design was used, and the initial weight was used as a covariate in data analysis. The go...

The aim of the study was to evaluate a hot-melt technique for preparation of immediate release spherical microparticles containing clarithromycin with acceptable characteristics and process yield. A modified fluid bed apparatus with rotor insert was used to prepare spherical microparticles in the size range of 125-355 µm. Poloxamer 188, PEG-32 glyceryl laurate (Gelucire 44/14) and a mixture of ...

Bicalutamide is the most widely used non-steroidal antiandrogen for treating early stage prostate cancer, but suffers variable oral absorption due to its limited aqueous solubility. Thus, our objective was to synthesize novel biodegradable copolymers for the systemic micellar delivery of bicalutamide. Flory-Huggins interaction parameter (cFH) was used to assess compatibility between bicalutamid...

The selection of sieving polymer for RNA fragments separation by capillary electrophoresis is imperative. We investigated the separation of RNA fragments ranged from 100 to 10,000 nt in polyethylene glycol (PEG) and polyethylene oxide (PEO) solutions with different molecular weight and different concentration. We found that the separation performance of the small RNA fragments (<1000 nt) was im...

Acute lymphoblastic leukemia (ALL) accounts for almost 4000 cases annually in the United States, approximately two thirds of which are in children and adolescents. Treatment results of ALL have improved considerably in the past decade, due to an optimal stratification of patients and a rational use of different antileukemic agents among which L-asparaginase (L-ASNase) plays a fundamental role. ...

Open-graded friction course (OGFC) is prone to deformation-related clogging during summer owing high internal temperature. Reducing OGFC temperature has significant benefits in relation mitigation of rutting and problems. A phase change composite material with PEG-4000 serving as the core SiO2 shell (PEG/SiO2) was used modify OGFC. Different mechanical performance tests were conducted, results ...