MSK pain may be due to rheumatic or nonrheumatic causes. Nonrheumatic causes are more common, generally benign, and most often attributable to trauma, overuse, and normal bone growth.5 Rheumatic causes, such as inflammatory arthritis, are infrequent, generally chronic, and require accurate, timely diagnosis and effective intervention to prevent progression and long-term damage.6 Common rheumati...

Introduction Macrophage Activation Syndrome (MAS) is a severe complication of rheumatic diseases, frequently associated with systemic juvenile idiopathic arthritis (sJIA), but also described in others pediatric inflammatory disorders including Juvenile Systemic Lupus Erythematosus (SLE) and Kawasaki disease. Due to the close resemblance to a group of histiocytic disorders collectively known as ...

Background and objectives Pediatric-onset inflammatory myositis (IM) and systemic lupus erythematosus (SLE) are rare inflammatory diseases. They result from the complex interaction between genetic and environmental factors. An increasing number of Mendelian conditions predisposing to the development of SLE have been recently identified. They mostly include monogenic conditions, especially type ...

Systemic lupus erythematosus (SLE) is an autoimmune disease associated with high morbidity and mortality, often caused by infection. We report two patients with SLE who were treated with steroids and immunosuppressive medication and then developed invasive Group B Streptococcus (GBS) infections. While GBS infection is rare in the nonneonatal pediatric age group, GBS should be considered when tr...

Purpose Recent studies have implicated low vitamin D levels with greater disease activity in pediatric systemic lupus erythematosus (SLE) and we have reported an association between low vitamin D levels and greater disease activity in juvenile dermatomyositis. The objective of this study was to explore whether standardized vitamin D supplementation of low levels of 25-hydroxyvitamin D [25(OH)D]...

Introduction Reduction of ovarian reserve has been observed in childhood-onset SLE (c-SLE) and adult SLE populations, and most of them were limited to follicle stimulating hormone (FSH) levels and few recent reports included antral follicle count (AFC) and/or anti-Müllerian hormone (AMH) levels. In addition, the contribution of diminished follicle ovarian pool using anti-corpus luteum antibodie...

Antiphospholipid syndrome is a multisystem autoimmune disease , characterized by arterial and venous thrombosis, recurrent fetal loss, and persistent circulating antiphospholipid antibodies [1]. This syndrome with protean clinical manifestations can be either primary or secondary to other autoimmune disease, mainly systemic lupus erythematosus. Whereas APS in adults has been well characterized,...

objective systemic lupus erythematosus (sle), an autoimmune systemic disease with unknown etiology, affects virtually every part of the body; involvement of the central nervous system (cns) is one of the major causes of morbidity and mortality in systemic lupus erythematosus (sle) patients and is the least understood aspect of the disease. neutropenia is very uncommon in childhood lupus. true n...