hepatitis a virus (hav) infection is a self-limiting disease caused by a 27-nm rna virus from the picorna virus family. its' transmission is primarily via the fecal-oral route. the disease is usually mild and anicteric in children, however the rate of the icteric form, severity, and mortality increase in adult life. the estimated case-fatality rate in age over 40 years is approximately 2%, whil...

BACKGROUND Fabry disease is an underdiagnosed, treatable, X-linked, multisystem disorder. OBJECTIVES To test the hypothesis that quality of life and sweating are decreased among pediatric patients with Fabry disease, compared with control subjects, and to provide quantitative natural history data and novel clinical end points for therapeutic trials. DESIGN Prospective, cross-sectional, obse...

From the Servicio d Guadalajara, Guadal lidades Médicas, U zServicio de Radiolo dalajara, and the §In Madrid, Spain. Address correspondence Jiménez, PhD, Cen Hospital 12 de Octub (e-mail: moranjimen The authors report no co Copyright # 2016 by E Hepatology, and Nu Gastroenterology, H article distributed un tion-Non Commerci where it is permissib properly cited. The commercially withou DOI: 10.1...

Doubly committed subarterial (supracristal) Residual VSD (by color and pulsed-wave Doppler and with contrast), although small leaks are acceptable at the borders of the patch. Residual or new aortic insufficiency compared with prebypass findings. RVOT obstruction or pulmonary regurgitation. Minimal PI may be acceptable. Muscular, Apical, Inlet Residual VSD (by color and pulsed-wave Doppler and ...

OBJECTIVES There is a pressing need for drug development in pediatric ulcerative colitis (UC). Lack of scientific consensus on efficacy endpoints and disease outcome assessments presents a hurdle for global drug development in pediatric UC. Scientists from 4 regulatory agencies convened an International Inflammatory Bowel Disease Working Group (i-IBD Working Group) to harmonize present thinking...

The benefits of play-based occupational therapy for hospitalized children with cancer warrant further exploration. Pediatric cancer disease symptoms, complications from treatment, and multiple and prolonged hospitalizations restrict participation in the daily activities of a child’s life. However, occupational therapy services in pediatric oncology are limited because of the disease nature, tre...

OBJECTIVE Limited information exists on features of pediatric Selective IgM immunodeficiency (SIgMID). Previously published pediatric cases and 2 new cases are reviewed. METHODS English literature from PubMed and references from relevant articles were reviewed. Previously reported cases and 2 new cases from an allergy/immunology practice were analyzed. RESULTS Forty-nine reported cases of S...

A workgroup meeting on the use of family history information in pediatric primary care and public health sponsored by the National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention was held February 24 to 25, 2006. The workgroup participants met to discuss how to improve the use of family history information in pediatric settings. Topics ad...

Natural History of Pediatric Crohn Disease T he natural history of pediatric Crohn disease (CD) remains unpredictable, although some trends are observed that differentiate children from adults. Pediatric CD often presents with more severe disease and more frequent need for immunosuppressive therapy (1). Growth failure, present in 15% to 20% of patients, is a unique characteristic of pediatric C...