نتایج جستجو برای: pediatric abdominal malignancies
تعداد نتایج: 248908 فیلتر نتایج به سال:
Introduction: According to the results of studies from different parts of the world, malignancies in children are rare. Despite this fact, malignant neoplasms remain the second leading cause of death in children after accidents. ALL, CNS tumors and lymphomas are the most common malignancies in children. They account for approximately more than 50% of malignancies and occur more frequently in b...
At the time of writing, five anti-CD19 CAR T-cell products are approved by U.S. Food and Drug Administration for seven different indications in lymphoid malignancies, including B-cell non-Hodgkin lymphoma, pediatric acute lymphoblastic leukemia, multiple myeloma. T cells chronic lymphocytic myeloid less common malignancies such as lymphomas Hodgkin lymphoma being tested early-phase clinical tri...
Morbidity and mortality associated with pediatric malignant primary brain tumors remain high in the absence of effective therapies. Macrophage-mediated phagocytosis of tumor cells via blockade of the anti-phagocytic CD47-SIRPα interaction using anti-CD47 antibodies has shown promise in preclinical xenografts of various human malignancies. We demonstrate the effect of a humanized anti-CD47 antib...
One of the most common hematologic malignancies in adults, myelodysplastic syndrome (MDS) is a heterogenous group of clonal disorders characterized by peripheral cytopenia(s) and normal or hypercellular bone marrow with dysplasia in ≥1 blood cell lineages. MDS frequently evolves to secondary acute myeloid leukemia with poor prognosis. Although uncommon among pediatric hematologic malignancies, ...
A cystic lymphangioma arising within the abdomen is a rare entity in children. It may present with an abdominal mass and symptoms of abdominal pain, vomiting, and anorexia. These nonspecific clinical symptoms are often attributed to more common acute pediatric conditions. In this report, we describe two pediatric cases of intra-abdominal cystic lymphangioma that were initially diagnosed and tre...
BACKGROUND Undifferentiated embryonal sarcoma (UES) of liver is a rare malignant neoplasm, which affects mostly the pediatric population accounting for 13% of pediatric hepatic malignancies, a few cases has been reported in adults. CASE PRESENTATION We report a case of undifferentiated embryonal sarcoma of the liver in a 20-year-old Caucasian male. The patient was referred to us for further i...
Cancer is a major cause of childhood death, with central nervous system (CNS) neoplasms being the second most common pediatric malignancy, following hematological cancer. Treatment of pediatric CNS malignancies requires multimodal treatment using a combination of surgery, chemotherapy, and radiotherapy, and advances in these treatments have given favorable results and longer survival. However, ...
We present a 13.5 year old boy with chronic intussusception that was misdiagnosed as Crohn disease and received treatment for the wrong diagnosis. Because his condition didn’t improve, more work-ups were performed and the radiologic work-ups revealed the diagnosis of a missed intussusception with fistula.We suggest that prolonged intussusception should be considered in the list of differential ...
Background: Pediatric pancreatic malignancies are extremely rare with an age population-adjusted incidence of 0.018 cases per 100,000. In adolescent girls, they usually present as solid pseudopapillary neoplasms[SPNs], low-grade malignant tumors of the exocrine pancreas. Due to their rarity and nonspecific clinical presentation, SPNs are frequently misdiagnosed. The treatment of choice is a com...
The use of immune checkpoint inhibitors as therapy in adult patients with malignancy has resulted an improvement overall survival. Research on the these drugs pediatric oncology is just beginning. However, results already obtained indicate possibility successful children Hodgkin’s lymphoma and some subtypes non-Hodgkin’s lymphomas. This review analyzes studies nivolumab pembrolizumab for treatm...
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