A multifunctional reagent based on a coumarin scaffold was developed for derivatization of naive RNA. The alkylating agent N3BC [7-azido-4-(bromomethyl)coumarin], obtained by Pechmann condensation, is selective for uridine. N3BC and its RNA conjugates are pre-fluorophores which permits controlled modular and stepwise RNA derivatization. The success of RNA alkylation by N3BC can be monitored by ...

We consider the Dirichlet eigenvalues of Laplacian among a Poissonian cloud hard spherical obstacles fixed radius in large boxes $\mathbb{R}^d$, $d \ge 2$. In box side-length $2l$ centered at origin, lowest eigenvalue is known to be typically order $(\log l)^{-2/d}$. show here that with probability arbitrarily close $1$ as $l$ goes infinity, spectral gap stays bigger than $\sigma (\log l)^{-(1 ...

This year the Annual Meeting in Berlin (September 15th to 17th) was 25th one of German Society Travel Medicine and therefore it included some celebration. The scientific part a wide variety topics. Beside ‘typical’ ones like malaria prevention new vaccines there were lectures about space tourism (Prof. R. Gerzer), environmental risks (earthquakes – Dr. J. Lauterjung, altitude medicine S. Baniya...

In this work, a multifunctional yellowing inhibitor was synthesized by the Pechmann method. In order to obtain the target compound, 7-hydroxy-4methyl coumarin was prepared by using the raw materials of resorcinol and ethyl acetoacetate, with toluene-p-sulfonic acid as the catalyst. New polymeric fluorescent compounds were synthesized by connecting the 7hydroxy-4-methyl coumarin, the hindered am...

The word class effect in the picture-word interference paradigm is a highly influential finding that has provided some of the most compelling support for word class constraints on lexical selection. However, methodological concerns called for a replication of the most convincing of those effects. Experiment 1 was a direct replication of Pechmann and Zerbst (2002; Experiment 4). Participants nam...