Peanut allergy is an increasing global health problem, which affects 1--3% of children in Western countries. The prevalence may have tripled in the last 15 years, which constitutes approximately 100,000 new cases annually in the USA and Canada.1--3 The most recent evidence, challenging the current guidelines, highlights the benefits of early introduction of peanuts, rather than avoidance, durin...

INTRODUCTION Peanut allergy is an increasingly serious disorder with a heterogeneous pattern of sensitization across different countries. In vitro diagnostic techniques may help in establishing these patterns. OBJECTIVES To analyze the usefulness of determining specific immunoglobulin E (sIgE) with the ImmunoCAP fluorescence enzyme immunoassay (FEIA), the ImmunoCAP ISAC CRD103 microarray (ISA...

BACKGROUND Peanut allergy (PA) is rare in countries in which peanuts are introduced early into infants' diets. Learning Early About Peanut Allergy (LEAP) is an interventional study aiming to assess whether PA can be prevented by oral tolerance induction. OBJECTIVE We sought to characterize a population screened for the risk of PA. METHODS Subjects screened for the LEAP interventional trial ...

In Spain, peanut allergy is increasingly prevalent. Successful protocols for the induction of oral tolerance (LOT) with several foods have been reported. We aimed to induce clinical tolerance to peanut in a child with severe peanut allergy (age 4 years, facial urticaria and lip angioedema upon licking a peanut; peanut skin prick test, 13 x 10 mm; specific immunoglobulin (Ig) E > 100 kUA/L). At ...

Our knowledge about the time trend of cow’s milk allergy prevalence is very limited, however there some indirect data favoring the increase of the cow’s milk allergy prevalence. There are several studies reporting that food allergy is increased among children of all ages, both gender and different races/ethnicities. Several national health surveys in USA recently indicated that food allergy pre...

Allergy to cow's milk, egg, wheat, soy, peanut, tree nuts, fish, and shellfish constitutes the majority of food allergy reactions, but reliable estimates of their prevalence are lacking. This systematic review aimed to provide up-to-date estimates of their prevalence in Europe.Studies published in Europe from January 1, 2000, to September 30, 2012, were identified from searches of four electron...

BACKGROUND Threshold levels for peanut allergy determined by using oral challenges are important for the food industry with regard to allergen labeling. Moreover, the utility of biological markers in predicting threshold levels is uncertain. OBJECTIVE We sought to use a modified oral food challenge regimen that might determine threshold levels for peanut allergy mimicking a more real-life exp...

BACKGROUND It is hypothesized that household exposure to allergenic proteins via an impaired skin barrier, such as atopic dermatitis, may contribute to the development of IgE sensitization. Household presence of peanut is a risk factor for the development of peanut allergy in children. Sunflower seed butter is a peanut-free alternative to peanut butter, and sunflower seed allergy is an uncommon...

BACKGROUND Oral challenges are the gold standard in food allergy diagnostic, but time-consuming. Aim of the study was to investigate the role of peanut- and hazelnut-component-specific IgE in the diagnostics of peanut and hazelnut allergy and to identify cutoff levels to make some challenges superfluous. METHODS In a prospective and multicenter study, children with suspected peanut or hazelnu...

Food allergy is more common in infants and children (~6% under 3 years of age) than in adolescents and adults (~3.5%). 1 The epidemiology of food allergy is influenced by cultural and geographical dietary influences. In US studies of young children, cow's milk, hen's egg, peanut, wheat, and soybean account for the majority of significant food-allergic reactions. For adults, peanut, tree nuts (e...