A two-microelectrode voltage clamp and optical measurements of membrane potential changes at the transverse tubular system (TTS) were used to characterize delayed rectifier K currents (IK(V)) in murine muscle fibers stained with the potentiometric dye di-8-ANEPPS. In intact fibers, IK(V) displays the canonical hallmarks of K(V) channels: voltage-dependent delayed activation and decay in time. T...

Understanding the relationships between the rates and dynamics of current wave forms under voltage clamp conditions is essential for understanding phenomena such as state-dependence and use-dependence, which are fundamental for the action of drugs used as anti-epileptics, anti-arrhythmics, and anesthetics. In the present study, we mathematically analyze models of blocking mechanisms. In previou...

Although electrical heterogeneity within the ventricular myocardium has been the focus of numerous studies, little attention has been directed to the mechanical correlates. This study examines unloaded cell shortening, Ca(2+) transients, and inward L-type Ca(2+) current (I(Ca,L)) characteristics of epicardial, endocardial, and midmyocardial cells isolated from the canine left ventricle. Unloade...

Contractile behavior of the sheep cardiac Purkinje fiber was examined under voltage-clamp conditions in Tyrode's solution. For square depolarizing clamps to a given voltage, peak twitch tension depended on clamp duration if the duration was less than 80 to 90 msec, but measurable contractions could be obtained following 2-msec square clamps. Time to peak tension at 37°C remained constant as cla...

This research analyses the operation of a solar PV powered electric vehicle charging station with energy storage that has been developed and demonstrated at the University of California – Davis, West Village, the largest planned zero-energy consumption community in the U.S. The intelligent energy management approach introduces solar PV electrical energy forecasting and EV charging demand projec...

On-going changes in the electric utility industry are imposing ever-stricter constraints upon the operators of transmission networks. The increase in peak load and reduced power margins in the network may under certain circumstances conspire to produce brownouts, or even blackouts, especially when compounded with low probability contingencies. The challenge is also imposed on generation capacit...

The most complete definition for the voltage unbalance is using complex voltage unbalance factor (CVUF) that consists of its magnitude and angle. Unfortunately, the definition did not distinguish between undervoltage and overvoltage unbalance conditions. In this paper, the analysis of the motor is performed using the method of symmetrical component and MATLAB software is used to investigate the...

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Volatile anesthetics inhibit mammalian voltage-gated Na(+) channels, an action that contributes to their presynaptic inhibition of neurotransmitter release. We measured the effects of isoflurane, a prototypical halogenated ether volatile anesthetic, on the prokaryotic voltage-gated Na(+) channel from Bacillus halodurans (NaChBac). Using whole-cell patch-clamp recording, human embryonic kidney 2...

[1] We present a detailed investigation of X-ray emission from long laboratory sparks in air at atmospheric pressure. We studied 231 sparks of both polarities using a 1-MV Marx generator with gap lengths ranging from 10 to 140 cm. The X rays generated by the discharges were measured using five NaI/PMT detectors plus one plastic scintillator/PMT detector, all enclosed in 0.32-cm-thick aluminum b...