نتایج جستجو برای: pdgfra
تعداد نتایج: 1003 فیلتر نتایج به سال:
Gene amplification at chromosome 4q12 is a common alteration in human high grade gliomas including glioblastoma, a CNS tumour with consistently poor prognosis. This locus harbours the known oncogenes encoding the receptor tyrosine kinases PDGFRA, KIT, and VEGFR2. These receptors are potential targets for novel therapeutic intervention in these diseases, with expression noted in tumour cells and...
Glioblastoma multiforme (GBM) is the most aggressive human primary brain cancer. Using a Trp53-deficient mouse model of GBM, we show that genetic inactivation of the Atm cofactor Atmin, which is dispensable for embryonic and adult neural development, strongly suppresses GBM formation. Mechanistically, expression of several GBM-associated genes, including Pdgfra, was normalized by Atmin deletion...
Communication between neighboring tissues plays a central role in guiding organ morphogenesis. During heart tube assembly, interactions with the adjacent endoderm control the medial movement of cardiomyocytes, a process referred to as cardiac fusion. However, the molecular underpinnings of this endodermal-myocardial relationship remain unclear. Here, we show an essential role for platelet-deriv...
A 54-year-old man with no significant past medical history presented with skin rash. Complete blood count showed awhite blood cell count of 64310/L (63%neutrophils, 2% eosinophils), hemoglobin 14 g/dL, and platelet count 166 3 10/L. Bone marrow evaluation showed a hypercellularmarrowwithmarked granulocytic hyperplasia (Figure 1). There was no increase in marrow eosinophils or fibrosis. No dyspl...
Endothelial cells (ECs) are critical for angiogenesis, and microRNAs play important roles in this process. We investigated the regulatory role of microRNAs in ECs of hepatocellular carcinoma (HCC) by examining the microRNA expression profile of human umbilical vein endothelial cells (HUVECs) in the absence or presence of human HCC cells, and identified miR-146a as the most highly upregulated mi...
PURPOSE The incidence of gastrointestinal stromal tumors (GISTs) harboring platelet-derived growth factor receptor alpha (PDGFRA) mutations is low, therefore further investigation of the efficacy of imatinib in this subgroup was needed. MATERIALS AND METHODS Patients with PDGFRA-mutant GISTs who received imatinib as primary therapy for advanced disease between January 2000 and June 2012 were ...
ObjectivesTo develop a mutation-based radiomics signature to predict response imatinib in Gastrointestinal Stromal Tumors (GISTs).MethodsEighty-two patients with GIST were enrolled this retrospective study, including 52 from one center that used the model, and 30 second validate it. Reference standard was mutational status of tyrosine-protein kinase (KIT) platelet-derived growth factor α (PDGFR...
Gastrointestinal stromal tumors (GISTs) are the most common sarcomas in humans. Constitutively activating mutations in the KIT or PDGFRA receptor tyrosine kinases are the initiating oncogenic events. Most metastatic GISTs respond dramatically to therapies with KIT/PDGFRA inhibitors. Asymptomatic and mitotically-inactive KIT/PDGFRA-mutant "microGISTs" are found in one third of adults, but most o...
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