alpha-Synuclein is a major component of the fibrillary lesion known as Lewy bodies and Lewy neurites that are the pathologic hallmarks of Parkinson's disease (PD). In addition, point mutations in the alpha-synuclein gene imply alpha-synuclein dysfunction in the pathology of inherited forms of PD. alpha-Synuclein is a member of a family of proteins found primarily in the brain and is concentrate...

In the late 1990s, mutations in the synaptic protein α-synuclein (α-syn) were identified in families with hereditary Parkinson's disease (PD). Rapidly, α-syn became the target of numerous investigations that have transformed our understanding of the pathogenesis underlying this disorder. α-Syn is the major component of Lewy bodies (LBs), cytoplasmic protein aggregate...

Alpha-synuclein (?S) is an intrinsically disordered protein (IDP) that abundantly present in the brain and associated with Parkinson's disease (PD). In spite of its abundance contribution to PD pathogenesis, exact cellular function ?S remains largely unknown. The ability remodel phospholipid model membranes combined biochemical studies suggests involved endocytosis. To unravel which route(s) st...

The phosphatase and tensin homologue (PTEN) and the Ciona intestinalis voltage sensitive phosphatase (Ci-VSP) are both phosphatidylinositol phosphate (PIP) phosphatases that contain a C2 domain. PTEN is a tumor suppressor protein that acts as a phosphatase on PIP3 in mammalian cell membranes. It contains two principal domains: a phosphatase domain (PD) and a C2 domain. Despite detailed structur...

In this paper we report on how to increase the selectivity of gas sensors by using fluoropolymer membranes. The mass transport of polar and non-polar gases through a polymer membrane matrix was studied by systematic selection of polymers with different degrees of fluorination, as well as polymers whose monomers have ether groups (-O-) in addition to fluorine groups (-F). For the study, a set of...

the gas separation performance of commercial ceramic titania and hybrid silica (hybsi®) membranes was assessed using the gas permeation and permporometry methods. results indicated that the hybsi® membranes have a hybrid surface containing regions covered by a polymeric matrix and others with inorganic pores. these membranes have high h2 selectivity, which increases significantly with temperatu...

A thin Pd-Ag alloy film, which will be applied to fabricate membranes for hydrogen separation, was successfully deposited using an electroplating technique. The plating solution for the formation of a thin Ag-rich Ag-Pd film for electric contact consisted of PdCl2, AgNO3, HBr, and HNO2. An improvement of the electrolytic bath was achieved by a pH control, which was kept constant at 6.6 and by t...

Plasmodesmata (PD) generate continuity between plant cells via the cytoplasm, endoplasmic reticulum (ER) and plasma membrane (PM), allowing movement of different classes of molecules between cells. Proteomic data indicates that the PD PM hosts many receptors and receptor kinases, as well as lipid raft and tetraspanin enriched microdomain associated proteins, suggesting the hypothesis that the P...

P lasmodesmata (PD), the intercellular channels that span plasma membranes and cell walls between adjacent plant cells, are unique structures that create cytoplasmic continuity, termed the symplast, between individual cells. Within a symplastic domain, a group of cells that are interconnected by PD are able to exchange a wide range of molecules, from ions and water to proteins and nucleic acids...