Introduction. In the genesis of Parkinson's disease (PD) clinical phenomenology the exact nature of the association between bradykinesia and affective variables is unclear. In the present study, we analyzed the gait characteristics and level of depression in PD and healthy volunteers. Methods. Patients with PD (n = 48) and healthy controls (n = 52) were recruited for the present study. Walking ...

OBJECTIVE To evaluate the expression of PD-L1 (programmed death 1 ligand 1, PD-L1) and its clinical significance in breast invasive ductal carcinoma. METHODS Tumor samples were collected from 64 cases of breast invasive ductal carcinoma patients, and tumor adjacent normal breast tissue were obtained as normal control. The expression of PD-L1 were examined by immunohistochemical staining and r...

The prognostic value of programmed death-ligand 1 (PD-L1) in gastric cancer (GC) remains controversial. To clarify this problem, we performed a meta-analysis of research studies identified in the PubMed, EMBASE and the Cochrane Library databases. A total of 1,901 patients in 10 studies were enrolled in this meta-analysis, and the pooled hazard ratio (HR) of 1.64 (95% CI 1.11 to 2.43; P = 0.01) ...

Precise detection and localization of faults in power transformer windings for ultimate protection is the key issue. The insulation quality in windings majorly determines the enduring transformers function. Achieving as accurate and efficient detection method of partial discharge (PD) in transformer windings is challenging. The occurrence of PD being primarily responsible for the transformers f...

Music teachers in urban, suburban, and rural communities face a multitude of challenges opportunities. To identify examine specific experiences that may be unique to general music teachers, we recruited six teacher-participants complete 5-week online professional development (PD) course for this exploratory study. We created teacher-led approach PD, implementing topics solutions generated by th...

In high voltage insulation systems, dielectric materials may be exposed to partial discharges (PD), which can lead equipment failures and safety hazards. Therefore, it is crucial detect characterize PD activity on the surface of systems. Techniques such as radio frequency signal analysis ultraviolet radiation emission detection are commonly used for this purpose. research study, an was conducte...

PURPOSE Oropharyngeal squamous cell carcinoma (OSCC) has been recognized as an immunosuppressive disease. Various mechanisms have been proposed for immune escape, including dysregulation of immune checkpoints such as the PD-1:PD-L1 pathway. We investigated the expression of programmed cell death-ligand 1 (PD-L1) in HPV-negative and HPV-positive OSCC to determine its prevalence and prognostic re...

BACKGROUND We investigated whether disease location influences survival in patients with peripheral arterial disease. METHODS AND RESULTS Patients (n = 12,731; mean age, 67.5 ± 12.7 years; 57.4% male) who underwent outpatient noninvasive lower extremity arterial evaluation were followed up for 5.9 ± 3.1 years for all-cause mortality. Peripheral arterial disease (n = 8930) was defined as a res...