Monoclonal antibodies targeting PD-1/PD-L1 signaling pathway have achieved unprecedented success in cancer treatment over the last few years. Atezolizumab is the first PD-L1 monoclonal antibody approved by US FDA for cancer therapy; however the molecular basis of atezolizumab in blocking PD-1/PD-L1 interaction is not fully understood. Here we have solved the crystal structure of PD-L1/atezolizu...

Parkinson's disease (PD) can include a progressive frontal lobe α-synucleinopathy with disability from cognitive decline and cortico-limbic dysregulation that may arise from bioenergetic impairments. We examined in PD frontal cortex regulation of mitochondrial biogenesis (mitobiogenesis) and its effects on Complex-I. We quantified expression of 33 nuclear genome (nDNA)-encoded and 7 mitochondri...

a palladium composite membrane was prepared via electroless plating technique using organic-inorganic method during activation process. the ceramic support surface was modified by two tio2-boehmite and one γ-alumina layers to avoid pd penetration in support pores. thin and defect-free pd composite membrane was obtained by creating a relative smoothness on the ceramic support and using pd nanopa...

Oxidative addition of N-(2-iodophenyl)formamide to Pd(dba)2 (dba = dibenzylideneacetone) in the presence of 4,4'-ditertbutyl-2,2'-bipyridine ((t)Bubpy) produces [Pd(C6H4NHCHO-2)I((t)Bubpy)] (1) which inserts 2-iodophenyl isocyanide to give [Pd{C(=NC6H4I-2)C6H4NHCHO-2}I((t)Bubpy)] (2). Dehydroiodination of 2 with Tl(acac) (acacH = acetylacetone) gives the stable Pd(IV) complex OC-6-35-[Pd{C,N,N-...

2-Hydroxy-4-n-5-bromoacetophenone oxime (HnPBAO) was developed as a new analytical reagent for the gravimetric determination of divalent palladium ion. In the pH range of 2.0 to 5.0, the reagent gave a light brown precipitate with Pd(II). Job’s method and mole ratio method revealed that the stoichiometry of the complex is 1:2 (metal : ligand). Beer’s law is obeyed upto 37.25 ppm of Pd(II) at 45...

The complex trans -[Pd(COOCH3)(H2O)(PPh3)2](TsO) (I) has been synthesized by reacting trans -[Pd(COOCH3)Cl(PPh3)2] with AgTsO in methanol. It has been characterized by IR, H and P NMR spectroscopy. Crystals of trans [Pd(COOCH3)(H2O)(PPh3)2](TsO) /(CH3OH) (II) have been obtained by re-crystallization of I in methanol. The structure of the complex has been determined by X-ray analysis. It shows a...

Mononuclear and dinuclear square planar palladium(II) complexes (denoted by [(hfac)Pd(II)(L-LH)] and [(hfac)Pd(II)(L-L)Pd(II)(hfac)], respectively) were synthesized. Here hfac(-), HL-L(-) and L-L(2-) denote hexafluoroacetylacetonato, monoprotonated and non-protonated bis-β-diketonato ligands, respectively. Three bis-β-diketones were used as HL-LH: 1,2-diacetyl-1,2-dibenzoylethane (denoted by da...

XAFS spectra of palladium(II) in concentrated HNO3/HClO4 acid mixtures have been recorded and analyzed. Structural parameters of the Pd(H2O)4(2+) complex and the mixed nitric Pd(NO3)2(H2O)2 complex, for the first time, were determined by the XAFS method. For pure 5 M HClO4 and for mixtures (0-0.3 M HNO3), the XAFS spectra of the 0.02 M Pd solutions are indeed very similar and originated from fo...