BACKGROUND In liver injury, the pool of hepatic stellate cell (HSC) increases and produces extracellular matrix proteins, decreasing during the resolution of fibrosis. The profibrogenic role of endothelin-1 (ET-1) in liver fibrosis remains disputed. We therefore studied the effect of ET-1 on proliferation, apoptosis and profibrogenic gene expression of HSCs. RESULTS First passage HSC predomin...

JACEK BOCHNIAK∗, KRZYSZTOF GAŁKOWSKI∗ ERIC ROGERS∗∗, ANTON KUMMERT∗∗∗ ∗ Faculty of Electrical Engineering, Computer Science and Telecommunications University of Zielona Góra Podgórna 50, 65–246 Zielona Góra, Poland e-mail: [email protected], [email protected] ∗∗ School of Electronics and Computer Science University of Southampton Southampton SO 17 1BJ, United Kingdom e-mail...

Pulmonary hypertension is rare in chronic respiratory diseases but has a strong impact on the prognosis and is partly underlined by factors other than hypoxaemia. The aim of the present study was to assess the potential role of endothelin-1 (ET-1) and nuclear factor (NF)-kappaB vasoconstrictive pathways in pulmonary hypertension. The effects of ET-1 receptors blockers (BQ 123 and 788) and of ge...

Ethionamide (ETA) is an important component of second-line therapy for the treatment of multidrug-resistant tuberculosis. Synthesis of radiolabeled ETA and an examination of drug metabolites formed by whole cells of Mycobacterium tuberculosis (MTb) have allowed us to demonstrate that ETA is activated by S-oxidation before interacting with its cellular target. ETA is metabolized by MTb to a 4-py...

S. Dymkou, E. Rogers, M. Dymkov, K. Ga lkowski, D. H. Owens 1 ITMS, Ballarat University, Australia. 2 Department of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UK. [email protected] 3 Institute of Mathematics, National Academy of Sciences of Belarus, Minsk, Belarus. 4 Institute of Control and Computation Engineering, University of Zielona Góra, Poland. ...

O reuso de água é uma necessidade global em virtude do crescimento da demanda tanto populacional quanto econômica. A falta preocupação com as fontes naturais água, alterações climáticas, além hábitos consumo acabam causando a diminuição potável. Organizações mundiais mostram esta situação, Organização Mundial Saúde (OMS), relatório aponta que quase 663 milhões pessoas no mundo vivem atualmente ...

When two membranes fuse, their components mix; this is usually described as a purely diffusional process. However, if the membranes are under different tensions, the material will spread predominantly by convection. We use standard fluid mechanics to rigorously calculate the steady-state convective flux of lipids. A fusion pore is modeled as a toroid shape, connecting two planar membranes. Each...

Establishment of a permissive pre-malignant niche in concert with mutant stem are key triggers to initiate skin carcinogenesis. An understudied area of research is finding upstream regulators of both these triggers. IL27, a pleiotropic cytokine with both pro- and anti-inflammatory properties, was found to be a key regulator of both. Two step skin carcinogenesis model and K15-KRASG12D mouse mode...

Os resíduos do tratamento de águas residuais são denominados lamas e devem também ser tratados para eliminação final. Seu inclui três objetivos principais: Estabilização da matéria orgânica, redução volume patógenos. A desidratação das é um passo essencial no processo, uma vez que a se traduz em maior facilidade menores custos transporte aterro. leitos secagem funcionam com fenómenos naturais p...