Centrosomes are major microtubule-nucleating organelles that facilitate chromosome segregation and cell division in metazoans. Centrosomes comprise centrioles that organize a micron-scale mass of protein called pericentriolar material (PCM) from which microtubules nucleate. During each cell cycle, PCM accumulates around centrioles through phosphorylation-mediated assembly of PCM scaffold protei...

The controversy of whether small asbestos fibers are biologically significant has not been resolved. The present standard method for evaluating asbestos fiber concentrations in workroom air excludes fibers less than 5 micron long even though it has been shown that small fiber concentrations dominate in a dust cloud. This research project was conducted to develop a mathematical model whereby one...

Phase Change Memory (PCM) has better scalability and smaller cell size comparing to DRAM. However, further scaling PCM cell in deep sub-micron regime results in significant thermal based write disturbance. Naively allocating large inter-cell space increases cell size from ideal 4F 2 to 12F 2. While a recent work mitigates write disturbance along word-lines through disturbance resilient data enc...

Phase change memory (PCM) is a byte-addressable type of non-volatile memory. Compared to other volatile and non-volatile memories, PCM is two to four times denser than dynamic random access memory (DRAM). It has better read latency than NAND flash memory. Even though the write endurance of PCM is 10 times better than NAND flash memory, it is still limited to times per PCM cell. When researchers...

Introduction The use of monolithic linear integrated circuits in PCM telemetry A/D converters is not new. As early as 1961-62, T. I. had built pure IC laboratory units, and in the period 1962-63, Fairchild and Radiation Inc. teamed to build an experimental PCM IC model. More recently, Autonetics and TRW Systems have claimed similar achievements. But none of the LIC’s used in these models has be...

Defect signal is always a problem that interferes with the operation of fibre board gluing control system. Complex problem analysis and solving are an important evolutionary direction of TRIZ. This research creates a defect diagnosis methodology by synthesizing the Theory of Inventive Problem Solving (TRIZ) and a Possibilistic C-Means (PCM) improved Support Vector Data Description (SVDD) method...

Protein carboxy-O-methyltransferase (PCM) activity was determined in subcellular fractions prepared from C-1300 neuroblastoma tumors following transplantation and growth in male A/J mice. Fractions were obtained by differential centrifugation, and PCM activity was determined in all fractions in the presence (+gel) and absence (-gel) of an exogenous substrate, gelatin. Sixty % of the PCM activit...

The derivation of a priority vector from a pair-wise comparison matrix (PCM) is an important issue in the Analytic Hierarchy Process (AHP). The existing methods for the priority vector derivation from PCM include eigenvector method (EV), weighted least squares method (WLS), additive normalization method (AN), logarithmic least squares method (LLS), etc. The derived priority vector should be as ...

BACKGROUND Paracetamol is recommended as first line agent for pain management in osteoarthritis (OA) by various guidelines. The main problem associated with management of osteoarthritis is long term patient compliance to paracetamol due to its frequent dosing. OBJECTIVE To evaluate the efficacy and safety of Paracetamol 650 mg dual release tablet twice daily (PCM 650 dual release) compared to...