Nanoscopic particles self-assembled from amphiphilic block copolymers have been developed over the past years for the preparation of various drug delivery systems. The biodegradable carriers made of polyethylene glycol (PEG)-polyester diblock copolymers emerged as the most adequate devices due to their prolonged circulation half-life in blood, their ability to bypass natural barriers, their red...

A folate conjugated ternary copolymer, FA-PEG-PEI-PCL, of poly(ethylene glycol) (PEG), poly(ethylene imine) (PEI), and poly(ɛ-caprolactone) (PCL) was synthesized. The copolymer self-assembled into cationic micelles capable of co-delivering siRNA and the anticancer drug doxorubicin (DOX). This dual functional nanocarrier demonstrated low cytotoxicity and high performance in drug/siRNA delivery. ...

In this work, poly(ethylene glycol) (PEG)/poly(ε-caprolactone) (PCL) semicrystalline networks were prepared by photo-cross-linking of methacrylated macromonomers with different molecular weights and in proportions to obtain amphiphilic materials capable displaying properly designed shape memory effects. Networks based on PCL 10 kDa PEG 3 showed suitable thermal mechanical properties well-separa...

Magnetic nanoparticles have been highly regarded because of their unique properties, such as hyperthermia, medicine control release, and diagnostic applications. The main aim of the current paper is to offer a new system for the modification of Fe3O4 (SPIONs) superparamagnetic nanoparticles physically and chemically with polymers through physical retention. These modified nanoparticles have bee...

We describe the fabrication of porous foams with shape memory triggering at body temperature. Employing a modified porogenleaching technique, functionalized poly(3-caprolactone) (PCL) and poly(ethylene glycol) (PEG) macromers are crosslinked via thiol–ene chemistry to generate highly porous foam scaffolds with shape memory capacity. The temperature at which shape change of these scaffolds occur...

Single crystals of poly(ethylene glycol) (PEG)-b-polystyrene (PS), PEG-b-poly(methyl methacrylate) (PMMA), PEG-b-polycaprolactone (PCL), and polyaniline (PANI)-b-PEG-b-PANI were developed from dilute solutions and thin molten films using self-seeding methodology. The PS and PMMA grafted chains were categorized in disordered nano-brushes; however, the PCL and PANI ones were grouped in ordere...