The aim of the present research was by Electron Paramagnetic Resonance (EPR) spectroscopy using spin trapping technique to study in vitro oxidation of severe mushroom toxin alpha amanitin and second to evaluate its in vivo effect on oxidative status in mice kidney tissue. During in vitro oxidation of alpha amanitin by PbO2 in presence of nitrosobenzene as a spin-trapping agent, a triplet EPR si...